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A case of eosinophilic cholecystitis: Radiologic-pathologic correlation.

Radiol Case Rep

October 2024

Department of Diagnostic Radiology, Osaka Medical and Pharmaceutical University, 2-7, Daigakumachi, Takatsuki-City, Osaka 569-8686, Japan.

Eosinophilic cholecystitis (EC) is a rare condition that is characterized by eosinophilic infiltration in the gallbladder wall. We report the case of a 35-year-old woman who presented with unremitting right upper quadrant pain for 1 month. Computed tomography showed a strongly enhanced inner layer of the gallbladder wall.

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Article Synopsis
  • There are very few cases of serrated lesions outside the low digestive tract, with only two traditional serrated adenomas (TSA) identified in the gallbladder prior to this report.
  • A polypoid lesion was incidentally found during gallbladder surgery for cholecystitis, displaying unique epithelial characteristics and genetic markers.
  • This case highlights an unusual TSA in the gallbladder that lacked typical genetic mutations, indicating the need for more research to better understand and manage these lesions.
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BACKGROUND Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare systemic vasculitic condition characterized by bronchial asthma and eosinophilia. While biliary involvement is uncommon in EGPA, we present a unique case of EGPA presenting as steroid-responsive sclerosing cholangitis and cholecystitis. This case highlights the importance of considering EGPA in the differential diagnosis of biliary diseases, especially in patients with a history of bronchial asthma.

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