Objective: To determine the incidence of vitamin D deficiency in orthopaedic trauma patients undergoing fracture surgery living in the Northwest United States.
Design: Retrospective observational cohort study.
Setting: Level 2 trauma center.
Patients: Two cohorts of patients undergoing fracture repair surgery during a 3-month period in winter and summer had serum vitamin D levels drawn at the time of surgery. One hundred three patients were reviewed in the winter cohort and 98 in the summer cohort.
Main Outcome Measure: Serum 25(OH) vitamin D levels of patients undergoing fracture repair surgery.
Results: Normal levels of vitamin D were considered to be between 32 and 80 ng/mL. Most patients in both cohorts were vitamin D insufficient. The average level for the winter cohort was 26.4 ng/mL, which was significantly lower than the average level for the summer cohort, 29.8 ng/mL (P = 0.03).
Conclusions: A high incidence of vitamin D insufficiency and deficiency likely exists across all age groups in orthopaedic trauma patients living in the Northwest United States and regions with similarly northern latitude. Further study is required to confirm improved fracture healing with normalization of serum vitamin D levels.
Level Of Evidence: Prognostic Level IV. See Instructions for Authors for a complete description of levels of evidence.
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http://dx.doi.org/10.1097/BOT.0b013e31825cf8fb | DOI Listing |
Int J Chron Obstruct Pulmon Dis
January 2025
Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, People's Republic of China.
Background: This study aims to investigate the association between vitamin D levels and the risk of severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD).
Methods: We conducted a prospective observational study with 636 COPD patients admitted for exacerbations between January 2021 and December 2022. Patients were categorized based on serum 25-hydroxyvitamin D levels: severe deficiency (<10 ng/mL), deficiency (10-20 ng/mL), insufficiency (20-30 ng/mL), or sufficiency (>30 ng/mL).
Front Nutr
January 2025
Department of Respiratory, The Third Affiliated Hospital, Beijing University of Chinese Medicine, Beijing, China.
Objective: Vitamin B6 is involved in regulating a variety of biological reactions in cell metabolism, and possesses antioxidant and anti-inflammatory biological functions. 5'-pyridoxal phosphate (PLP) is the main biologically active form of vitamin B6. There is currently no research on the correlation between serum PLP levels and chronic obstructive pulmonary disease (COPD) prevalence.
View Article and Find Full Text PDFFood Chem X
January 2025
Microbial and Pharmaceutical Biotechnology Laboratory, Department of Pharmacognosy and Phytochemistry, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, India.
This study aimed to fortify Jamun () juice with vitamin D to address vitamin D deficiency and boost health. A nanoemulsion of vitamin D was fabricated using a low-temperature (4-20C) sonication method and incorporated into the juice. The vitamin D fortified jamun juice (VDFJJ) exhibited a total polyphenol content of 14.
View Article and Find Full Text PDFJ Community Hosp Intern Med Perspect
January 2025
Division of Hospital Medicine, Johns Hopkins Community Physicians, Johns Hopkins Medicine, Baltimore, MD, USA.
Purpose: The diagnosis and management of hypercalcemia in hospitalized patients can be challenging. Hypercalcemia is often associated with significant morbidity and end-organ damage which may delay a patient's recovery.
Methods: We report a case series of three patients who underwent orthopedic procedures with intraoperative placement of vancomycin-loaded calcium sulfate beads.
Cureus
December 2024
Research and Development, MediBrains Social Welfare Foundation, Mumbai, IND.
Background Vitamin B12 deficiency, or cobalamin deficiency, is common among populations with low consumption of animal-based products, mainly in India, due to religious and socioeconomic factors, which significantly increase the deficiency rate. The condition has been characterized by a wide range of clinical and hematological symptoms, mainly affecting the blood and nervous system. This study aims to assess the clinical and hematological characteristics of patients with vitamin B12 deficiency and assess the therapeutic response to supplementation with vitamin B12.
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