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Multi-omics revealed activation of TNF-α induced apoptosis signaling pathway in testis of DEHP treated prepubertal male rat.
Reprod Toxicol
November 2024
Department of Urology, Peking University First Hospital, Beijing 100034, China; Institution of Urology, Peking University, Beijing 100034, China; Beijing Key Laboratory of Urogenital Diseases (Male) Molecular Diagnosis and Treatment Center, Beijing 100034, China. Electronic address:
Article Synopsis
- The study investigates the harmful effects of di-(2-ethylhexyl) phthalate (DEHP) exposure on the testes of prepubertal rats, focusing on its impact on reproductive health.
- DEHP exposure led to decreased testis weight, increased oxidative stress, structural disorganization of testes, and reduced numbers of spermatogenic and Sertoli cells, along with damaged mitochondria.
- The research revealed that DEHP activates the TNF-α apoptosis pathway, resulting in impaired spermatogenesis and increased apoptosis, with similar effects observed using the active metabolite mono-(2-ethylhexyl) phthalate (MEHP) in vitro.
In-utero exposure to real-life environmental chemicals disrupts gene expression within the hypothalamo-pituitary-gonadal axis of prepubertal and adult rams.
Environ Res
January 2025
School of Biodiversity, One Health and Veterinary Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, UK.
Environmental chemicals (ECs) have been associated with a broad range of disorders and diseases. Daily exposure to various ECs in the environment, or real-life exposure, has raised significant public health concerns. Utilizing the biosolids-treated pasture (BTP) sheep model, this study demonstrates that in-utero exposure to a real-life EC mixture disrupts hypothalamo-pituitary-gonadal (HPG) axis gene expression and reproductive traits in prepubertal (8-week-old, 8w) and adult (11-month-old) male sheep.
View Article and Find Full Text PDFPhotobiomodulation Improves Histological Parameters of Testis and Spermatogenesis in Adult Mice Exposed to Scrotal Hyperthermia in the Prepubertal Phase.
J Lasers Med Sci
September 2024
Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Article Synopsis
- The study investigates how photobiomodulation (PBM) affects the testis of prepubertal male mice exposed to heat stress, which is known to damage testicular health.
- Twenty-four male mice were divided into three groups: a control group, a hyperthermia group, and a hyperthermia plus PBM group, where heat was applied to induce stress and laser therapy was used to assess its protective effects.
- Results showed that the PBM treatment improved sperm quality, increased testicular cell counts, boosted testosterone levels, and reduced harmful oxidative stress, suggesting that laser therapy can help protect the testis from heat damage during critical developmental periods.
Ultrastructural changes in the spermatogenic cells of domestic chicken (Gallus gallus domesticus) observed at different reproductive stages.
Micron
December 2024
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, South Valley University, Qena 83523, Egypt; Department of Anatomy and Histology, Faculty of Veterinary Medicine, King Salman International University, Ras Sudr, Egypt.
Spermatogenesis is a complex process. It is the modification of progenitor spermatogonia into mature spermatozoa. The stages are similar in all-male vertebrates, as well as avian species.
View Article and Find Full Text PDFSemen analysis and reproductive hormones in boys with classical Hodgkin lymphoma treated according to the EuroNet-PHL-C2 protocol.
Hum Reprod
November 2024
Pediatric Oncology, Cancer Center Amsterdam, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Study Question: What is the impact of the EuroNet-PHL-C2 treatment for boys with classical Hodgkin lymphoma (cHL) on semen parameters?
Summary Answer: More than half of the patients (52%, n = 16/31) had oligozoospermia or azoospermia at 2 years from cHL diagnosis; particularly boys treated for advanced-stage cHL had low sperm counts and motility.
What Is Known Already: Chemotherapy and radiotherapy to the inguinal region or testes can impair spermatogenesis and result in reduced fertility. The EuroNet-PHL-C2 trial aims to minimize radiotherapy in standard childhood cHL treatment, by intensifying chemotherapy.
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