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Telomere shortening in donor cell-derived acute promyelocytic leukemia after allogeneic hematopoietic stem cell transplantation: a case report.
Ann Hematol
January 2025
Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, Komagome Hospital, 3-18-22 Honkomagome, Bunkyo-Ku, Tokyo, 113-8677, Japan.
Donor cell leukemia (DCL), in which malignancy evolves from donor's stem cells, is an infrequent complication of allogeneic hematopoietic stem cell transplantation. Acute promyelocytic leukemia (APL) derived from donor cell is extremely rare and only four cases have been reported to date. Herein we report a case of donor cell-derived APL developing 32 months after haploidentical peripheral blood stem cell transplantation using posttransplant cyclophosphamide for myelodysplastic syndromes.
View Article and Find Full Text PDFThe association between body roundness index and new-onset hyperuricemia in Chinese population: the Kailuan cohort study.
BMC Public Health
January 2025
Department of Rheumatology and Immunology, Kailuan General Hospital, North China University of Science and Technology, Tangshan, Hebei, China.
Background: This study aimed to investigate the potential relationship between the newly defined adiposity metric, the Body Roundness Index (BRI), which assesses central obesity, and the development of new-onset hyperuricemia.
Methods: In the Kailuan cohort study from 2006 to 2019, 91,804 eligible participants were included. A multivariate Cox regression model was used to test the correlation between BRI and hyperuricemia.
Association of non-highdensity lipoprotein cholesterol to highdensity lipoprotein cholesterol ratio (NHHR) and subsequent hypertension and heart diseases: findings from the CHARLS cohort.
Aging Clin Exp Res
January 2025
Department of Cardiology, Tianjin First Center Hospital, Tianjin, 300192, China.
Purpose: NHHR, the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol, is a novel lipid marker associated with the risk of heart diseases and various health conditions. However, there is limited evidence regarding the relationship between NHHR and the onset of hypertension and heart diseases. The aim of this study was to investigate the association between NHHR and the new-onset hypertension and heart diseases among the Chinese middle-aged and older general population.
View Article and Find Full Text PDFIntensified Induction Therapy for Newly Diagnosed, Localized Skeletal Ewing Sarcoma (ISG/AIEOP EW-1): A Randomized, Open-Label, Phase 3, Non-Inferiority Trial.
Pediatr Blood Cancer
January 2025
Osteoncology, Bone and Soft Tissue Sarcomas and Innovative Therapies Unit, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Background: Several studies have shown that the intensity of treatment in Ewing sarcoma has an impact on outcome. The present trial tested the non-inferiority of intensive, shorter, induction chemotherapy (25 weeks total treatment time) compared to the standard treatment (37 weeks) in non-metastatic Ewing sarcoma (ES) at onset.
Procedure: This national, multicenter, parallel, randomized, controlled, open-label, non-inferiority, phase III trial was conducted in 14 specialized hospitals in Italy.
Association Between Type 2 Diabetes Onset Age and Risk of Cardiovascular Disease and Mortality: Two Cohort Studies from United Kingdom and Hong Kong.
Diabetes Metab
January 2025
Department of Family Medicine and Primary Care, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong; Centre for Safe Medication Practice and Research, Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, the University of Hong Kong, Hong Kong; Advanced Data Analytics for Medical Science (ADAMS) Limited, Hong Kong S.A.R., China. Electronic address:
Objective: This study evaluated the association between age of onset of type 2 diabetes mellitus (T2DM) and risk of cardiovascular disease (CVD) and mortality.
Method: Two retrospective cohort studies were conducted using the electronic health record from United Kingdom (UK) and Hong Kong (HK) (2008-2013) on adults without CVD. 128,918 and 185,646 patients with newly diagnosed T2DM were assigned to the T2DM group, and control group included 5,052,770 and 3,159,396 patients without T2DM in UK and HK cohort, respectively.
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