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Optimising water storage for climate resilience: Geospatial targeting for small tanks rejuvenation in Sri Lanka.
J Environ Manage
January 2025
The World Bank, 1818 H Street, NW Washington, DC, 20433, USA.
Article Synopsis
- Climate change and recurrent droughts in Sri Lanka threaten agricultural communities, with many local water storage tanks out of service due to neglect.
- A National Prioritisation Index has been developed using a geospatial method to identify which small tanks require rejuvenation based on demand and supply needs from farming populations.
- The study identifies priority areas for tank restoration, mainly in Kurunegala and Anuradhapura, aiming to boost water security and resilience for vulnerable agricultural communities in Sri Lanka and beyond.
The importance of instant impact: What matters to long-term care staff and residents about taking part in research?
J Am Geriatr Soc
August 2024
Lawrence S. Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada.
Further research is needed to help improve both the standard of care and the outcome for patients with treatment-resistant depression. A particularly critical evidence gap exists with respect to whether pharmacological or non-pharmacological augmentation is superior to antidepressant switch, or vice-versa. The objective of this study was to compare the effectiveness of augmentation with aripiprazole or repetitive transcranial magnetic stimulation versus switching to the antidepressant venlafaxine XR (or duloxetine for those not eligible to receive venlafaxine) for treatment-resistant depression.
View Article and Find Full Text PDFB7-H3 Inhibitors in Oncology Clinical Trials: A Review.
J Immunother Precis Oncol
February 2024
Early Phase Clinical Trials Unit, Sarah Cannon Research Institute at HealthONE, Denver, CO, USA.
B7-H3 is a transmembrane receptor highly prevalent on malignant cells and plays an important role in adaptive immunity that is not fully elucidated. Targeted B7-H3 inhibitors, including antibody-drug conjugates, radioimmunotherapy, and monoclonal antibodies, are a new class of antineoplastic agents showing promising preliminary clinical efficacy, observed with several of these agents against multiple tumor types. Particularly promising treatments are enoblituzumab for prostate cancer, I-omburtamab for central nervous system malignancies, and HS-20093 for small-cell lung cancer but further studies are warranted.
View Article and Find Full Text PDFA female woolly mammoth's lifetime movements end in an ancient Alaskan hunter-gatherer camp.
Sci Adv
January 2024
Alaska Stable Isotope Facility, University of Alaska Fairbanks, AK, USA.
Woolly mammoths in mainland Alaska overlapped with the region's first people for at least a millennium. However, it is unclear how mammoths used the space shared with people. Here, we use detailed isotopic analyses of a female mammoth tusk found in a 14,000-year-old archaeological site to show that she moved ~1000 kilometers from northwestern Canada to inhabit an area with the highest density of early archaeological sites in interior Alaska until her death.
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