Background: Synthetic cannabinoids have recently gained popularity as recreational drugs because they provide a marijuana-like high and cannot be detected in typical urine drug screens. However, the use of synthetic cannabinoids may result in a variety of adverse effects.
Objectives: The intent of this investigation was to determine whether synthetic cannabinoid exposures in Texas demonstrated any geographic variation.
Methods: A total of 1037 synthetic cannabinoid exposures reported to Texas poison centers during 2010-2011 were identified and the county and Texas Public Health Region (PHR) where the call originated from ascertained. The distribution of exposures by county and PHR was determined.
Results: Synthetic cannabinoid exposures were reported in 124 of the 254 Texas counties (mean exposures per county 4.1, range 0-179). The exposure rate among the 11 PHRs varied from 2.79 to 7.14 per 100,000 population. The rate was 4.02 in urban counties and 4.90 in rural counties.
Conclusion: Synthetic cannabinoid exposures reported to Texas poison centers varied by geographic region. The rate tended to be higher in rural counties.
Scientific Significance: Such information may be useful when attempting to target education and prevention activities.
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http://dx.doi.org/10.3109/00952990.2012.670339 | DOI Listing |
J Appl Toxicol
March 2025
Department of Molecular Biology and Genetics, Science Faculty, Atatürk University, Erzurum, Türkiye.
Detailed studies on the embryotoxic and teratogenic effects of synthetic cannabinoids known to be abused are very limited. The present study aimed to evalutate the possible embryotoxic, teratogenic, behavioral, and molecular effects of 4F-MDMB-BUTICA, a new generation synthetic cannabinoid, using zebrafish embryos. The zebrafish embryos were exposed to the cannabinoid at 0.
View Article and Find Full Text PDFBackground: Male factor infertility (MFI) is responsible for 50% of infertility cases and in 15% of the cases sperm is absent due to germ cell aplasia. Human induced pluripotent stem cell (hiPSC)-derived spermatogonial stem cells (hSSCs) could serve as an autologous germ cell source for MFI in patients with an insufficient sperm yield for assisted reproductive technology (ART). The endocannabinoid system (ECS) has been implicated to play a role in mouse embryonic stem cells (mESCs) and the human testicular environment.
View Article and Find Full Text PDFPharmacol Res
March 2025
Department of Psychological and Brain Sciences, Indiana University Bloomington, Bloomington, IN, 47405 United States; Program in Neuroscience, Indiana University Bloomington, Bloomington, IN, 47405 United States; Gill Institute for Neuroscience, Indiana University, Bloomington, IN, 47405 United States. Electronic address:
Recreational use of synthetic cannabinoid agonists (i.e., "spice compounds") that target the cannabinoid type 1 receptor (CB) can cause acute respiratory failure in humans.
View Article and Find Full Text PDFACS Omega
March 2025
Department of Life Sciences, University of Bath, Bath BA2 7AY, U.K.
Synthetic cannabinoids (SCs) are novel psychoactive substances (NPS) that are highly potent and associated with a range of severe toxicities. SC use, which is common in UK prisons and homeless communities, typically involves combustion of SC-soaked herb or paper material. Recently, e-cigarettes (or vapes) have emerged as popular delivery vehicles for SCs, and consumption among the general population has risen significantly.
View Article and Find Full Text PDFCurr Addict Rep
August 2024
Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.
Purpose Of Review: In the alcohol research literature, many studies demonstrate the impact of advertisements, outlet density, and perceived norms on attitudes and behaviors. Now that Washington State has exceeded 11 years of legal cannabis for non-medical purposes, building upon the existing evidence base with alcohol, we can examine what contributes to perceived harm and availability with cannabis in a legal context and begin to explore opportunities for future research.
Recent Findings: In this commentary, we consider how cannabis with high THC concentration is viewed, explore trends surrounding impaired driving, discuss loopholes in legislation that have allowed for the emergence of synthetic cannabinoids, and examine pandemic-related decisions made by lawmakers related to cannabis use.
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