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Maternal and zygotic contributions to H3K4me1 chromatin marking during germ layer formation.
Dev Biol
February 2025
Developmental and Cell Biology, University of California, Irvine, CA, USA; Center for Complex Biological Systems, University of California, Irvine, CA, USA. Electronic address:
An early step in triploblastic embryo differentiation is the formation of the three germ layers. Maternal pioneer transcription factors (TFs) bind to embryonic enhancers before zygotic genome activation, initiating germ layer specification. While maternal TFs' role in establishing epigenetic marks is known, how early pluripotent cells gain spatially restricted epigenetic identities remains unclear.
View Article and Find Full Text PDFCell lineage-guided mass spectrometry reveals increased energy metabolism and reactive oxygen species in the vertebrate organizer.
Proc Natl Acad Sci U S A
February 2024
Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742.
Molecular understanding of the vertebrate Organizer, a tissue center critical for inductive signaling during gastrulation, has so far been mostly limited to transcripts and a few proteins, the latter due to limitations in detection and sensitivity. The Spemann-Mangold Organizer (SMO) in the South African Clawed Frog (), a popular model of development, has long been known to be the origin of signals that pattern the mesoderm and central nervous system. Molecular screens of the SMO have identified several genes responsible for the ability of the SMO to establish the body axis.
View Article and Find Full Text PDFThe human LIN28B nucleosome is inherently pre-positioned for efficient binding of multiple OCT4s without H3 K27 acetylation.
bioRxiv
October 2023
Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Pioneer transcription factors possess the unique ability to access DNA within tightly packed chromatin structures, playing pivotal roles in cell differentiation and reprogramming. However, their precise mechanism for recognizing nucleosomes has remained mystery. Recent structural and biochemical investigations into the binding interactions between the human pioneer factor OCT4 and the LIN28B nucleosome by Sinha et al.
View Article and Find Full Text PDFBi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive and complex movement disorders.
Brain
April 2024
Department of Neuromuscular Diseases, UCL Institute of Neurology, London WC1N 3BG, UK.
Article Synopsis
- The protein ACBD6 is important for lipid and protein acylation, but its exact role and effects of its defects on human health remain unclear.
- Researchers found 45 individuals from 28 families with harmful mutations in ACBD6, leading to a variety of severe developmental and movement disorders.
- Model organisms like zebrafish and Xenopus were used in studies to better understand ACBD6's function in protein modification and its localization in peroxisomes, which could help explain the associated disease symptoms.
Extrusion fountains are hallmarks of chromosome organization emerging upon zygotic genome activation.
bioRxiv
July 2023
Department of Developmental Biology, University of Freiburg, Freiburg, 79104, Germany.
The first activation of gene expression during development (zygotic genome activation, ZGA) is accompanied by massive changes in chromosome organization. The connection between these two processes remains unknown. Using Hi-C for zebrafish embryos, we found that chromosome folding starts by establishing "fountains", novel elements of chromosome organization, emerging selectively at enhancers upon ZGA.
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