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Semaglutide and laparoscopic sleeve gastrectomy in an adolescent with congenital adrenal hyperplasia due to 21-hydroxylase: a case report.
J Med Case Rep
January 2025
Department of Surgery, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of USC, Los Angeles, CA, USA.
Background: Classic congenital adrenal hyperplasia, primarily due to 21-hydroxylase deficiency, leads to impaired cortisol and aldosterone production and excess adrenal androgens. Lifelong glucocorticoid therapy is required, often necessitating supraphysiological doses in youth to manage androgen excess and growth acceleration. These patients experience higher obesity rates, hypertension, and glucose metabolism issues, complicating long-term health management.
View Article and Find Full Text PDFDiversity-oriented synthesis of stereodefined tetrasubstituted alkenes via a modular alkyne gem-addition strategy.
Nat Commun
January 2025
School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China.
Stereocontrolled construction of tetrasubstituted olefins has been an attractive issue yet remains challenging for synthetic chemists. In this manuscript, alkynyl selenides, when treated with ArBCl, are subject to an exclusive 1,1-carboboration, affording tetrasubstituted alkenes with excellent levels of E-selectivity. Detailed mechanistic studies, supported by DFT calculations, elucidates the role of selenium in this 1,1-addition process.
View Article and Find Full Text PDFHighly printable, strong, and ductile ordered intermetallic alloy.
Nat Commun
January 2025
Department of Materials Science and Engineering, College of Engineering, City University of Hong Kong, Hong Kong, China.
Ordered intermetallic alloys are renowned for their impressive mechanical, chemical, and physical properties, making them appealing for various fields. However, practical applications of them have long been severely hindered due to their severe brittleness and poor fabricability. It is difficult to fabricate such materials into components with complex geometries through traditional subtractive manufacturing methods.
View Article and Find Full Text PDFOcean current modulation of the spatial distribution of microplastics in the surface sediments of the Beibu Gulf, China.
J Hazard Mater
January 2025
School of Chemistry and Environment, Guangdong Provincial Observation and Research Station for Tropical Ocean Environment in Western Coastal Water, Guangdong Ocean University, Zhanjiang 524088, China.
Microplastic pollution, a major global environmental issue, is gaining heightened attention worldwide. Marginal seas are particularly susceptible to microplastic contamination, yet data on microplastics in marine sediments remain scarce, especially in the Beibu Gulf. This study presents a large-scale investigation of microplastics in the surface sediments of the Beibu Gulf to deciphering their distribution, sources and risk to marginal seas ecosystems.
View Article and Find Full Text PDFUse of the structured emergency nursing framework HIRAID® improves patient experience: A stepped-wedge cluster randomised control trial in rural, regional and metropolitan Australia.
Intensive Crit Care Nurs
January 2025
Faculty of Medicine and Health, The University of Sydney Susan Wakil School of Nursing and Midwifery Camperdown NSW Australia; Western Sydney Local Health District, North Parramatta, NSW 2141, Australia. Electronic address:
Background: Emergency departments have high levels of uncertainty, long wait times, resource shortages, overcrowding and a constantly changing environment. Patient experience and patient safety are directly linked, yet levels of patient experience are stagnant. To improve emergency nursing care and patient experience, an emergency nursing framework HIRAID® (History including Infection risk, Red flags, Assessment, Interventions, Diagnostics, communication, and reassessment) was implemented in 29 Australian emergency departments.
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