[Estimation of pulse pressure in subjects with carbohydrate disorders].

Unlabelled: Carbohydrate disorders are important and independent risk factor for cardiovascular system diseases. Increased values of pulse pressure are an independent risk factor for cardiovascular complications and total mortality. The aim of the study was to evaluate the pulse pressure in subjects with carbohydrate disorders.

Material And Methods: The study comprised 112 subjects with carbohydrate disorders (54 females and 58 males), aged 30-78 (57.4 +/- 9.6) years. Carbohydrate disorders were diagnosed according to the Polish Diabetes Association criteria from 2007 (group 1). 56 subjects had impaired fasting glucose (IFG), 36--impaired glucose tolerance (IGT) and 20--type 2 diabetes. Comparative group comprised 30 subjects without cardiovascular diseases and carbohydrate disorders (15 females and 15 males), aged 29-64 (52.7,4 +/- 8.8) years (group II). The fasting serum glucose level was evaluated using an enzymatic method, Kone-Pro biochemical analyzer and bioMérieux Glucose RTU kit. In subjects with fasting glucose level > or = 100 mg/dl, an oral glucose tolerance test (OGTT) was performed. In all subjects 24-h ambulatory blood pressure monitoring with oscillometric method, using boso-TM-2430PL system (Bosch+Sohn, Germany). Pulse pressure (pp) was evaluated as a mean difference between the systolic and diastolic pressure.

Results: In subjects with carbohydrate disorders the mean value of pp was 56.79 +/- 16.28 mmHg and it was significantly higher (p < 0.05) than in comparative group (49.0 +/- 11.1 mmHg). Increased value of pp (> 63 mmHg) was found significantly more often in group with carbohydrate disorders (46% vs 10%) (p < 0.05). On the basis of ROC curve analysis and OR (odds ratio) it was shown that pp > or = 52.5 mmHg results in a threefold increased risk of carbohydrate disorders.

Conclusions: Increased values of pulse pressure are found significantly more often in subjects with carbohydrate disorders. The risk of carbohydrate disorders increases threefold in subjects with pp > or = 52.5 mmHg.