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Development and validation of a nomogram for predicting cough variant asthma diagnosis.
BMC Pulm Med
January 2025
Department of Pulmonary and Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215006, China.
Background: Cough variant asthma (CVA) is a specific type of asthma characterized by chronic cough as the sole or predominant symptom. Accurate diagnosis is crucial for effective treatment, yet bronchial provocation test is not always feasible in clinical settings. To identify independent predictors of CVA diagnosis, we developed a nomogram for predicting CVA.
View Article and Find Full Text PDFNasal food challenge with hen's egg white allergen.
Allergy Asthma Clin Immunol
January 2025
Department of Prevention of Environmental Hazards, Allergology and Immunology, Medical University of Warsaw, Zwirki I Wigury 61, 02-097, Warsaw, Poland.
Background: Nasal allergen provocation tests are an important part of the diagnostics of allergic diseases triggered by environmental factors. Recently, increased attention has been paid to the potential use of this method in the diagnosis of food allergy. The objective of the study was to evaluate the usefulness of the nasal allergen provocation test in a group of subjects allergic to hen's egg white allergens.
View Article and Find Full Text PDFThe Role of Basophil Activation Test in the Diagnosis of Pediatric Egg Allergy in Turkey: A Comparison of Clinical and Laboratory Findings with Real-Life Data.
Allergol Immunopathol (Madr)
January 2025
Faculty of Medicine, Department of Pediatric Allergy and Immunology, Ondokuz Mayıs University, Samsun, Turkey.
Background: Egg allergy is among the most common food allergies in children, significantly affecting the dietary habits and quality of life of both the affected children and their families. This study aims to assess the clinical role of the Basophil Activation Test (BAT) in children with egg allergy and to evaluate its diagnostic accuracy in comparison to other tests.
Methods: The study included 46 children with egg allergy.
Transcriptomic Profiles of the Nasal Mucosa Following Birch Pollen Provocation Differ Between Birch Pollen-Allergic and Non-Allergic Individuals.
Allergy
December 2024
Department of Dermatology, University Hospital St. Poelten, Karl Landsteiner University of Health Sciences, St. Poelten, Austria.
Article Synopsis
- Birch pollen (BP) exposure leads to significant changes in gene expression and cytokine levels in allergic individuals compared to non-allergic individuals, indicating distinct biological responses.
- RNA sequencing identified 160 genes activated in allergic participants, with specific pathways related to inflammation and immune response being enriched in their nasal secretions.
- The findings suggest that BP allergy triggers unique signaling mechanisms in predisposed individuals, providing insights for future research into allergy treatments.
Direct oral provocation test with beta-lactams in Brazilian children and adolescents.
J Pediatr (Rio J)
December 2024
Universidade do Estado do Rio de Janeiro (UERJ), Faculdade de Ciências Médicas, Departamento de Pediatria, Rio de Janeiro, Brazil.
Article Synopsis
- Beta-lactam allergy is a significant public health concern, especially among Brazilian children and adolescents, and this study aims to evaluate the safety of direct Oral Provocation Tests (OPT) for this group.
- A cross-sectional study involved 54 children aged 1 to 17 with mild reactions to penicillin, using amoxicillin for the testing, and employed statistical methods to analyze results.
- The findings indicated that over 90% of participants were no longer considered allergic, with only a 7.5% positivity rate for the tests, and no serious reactions were reported, suggesting that the OPT is safe but calling for further research on its duration.
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