Few educational studies have investigated how well information learned by medical students is retained over time. The primary aim of this study was to investigate how much of the paediatric core curriculum undergraduates remembered a year after originally passing their paediatrics examination. In addition, we looked at whether students' repeat performance is related to their approach to learning. Medical students were presented with 8 out of a possible 46 core curriculum short answer questions (Mark 1). A year later these same students were re-tested, without prior warning, on the same 8 questions (Mark 2) and a further 8 questions (Mark 3) from the bank of 46. The participants also completed the Revised two-factor Study Process Questionnaire to characterise their approach to learning. After a year, students scores had diminished by 51.2 % (95 % CI 48.2-54.2 %, p < 0.0001) from a Mark 1 average of 89.1 % (standard deviation, SD = 9.2 %) to a Mark 2 average of 37.9 % (SD 6.1 %). Students who reported a superficial approach to learning achieved higher scores for mark 1 (4.1 % increase (95 % CI 0.9-7.4 %) per one standard deviation unit increase in Surface Approach score (p = 0.01)). Neither deep nor surface approach to learning significantly predicted performance a year later (Marks 2 and 3). Students had forgotten more than half of the paediatric core curricular content that they had previously proven that they knew for their summative assessment. Adopting either a deep or superficial approach to learning did not predict ability to retain this information a year later.
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ACS Appl Mater Interfaces
January 2025
Key Laboratory of Functional Polymer Materials of Ministry of Education, College of Chemistry, Nankai University, Tianjin 300071, China.
CRISPR/Cas9 (CRISPR, clustered regularly interspaced short palindromic repeats) gene editing technology represents great promise for treating glioblastoma (GBM) due to its potential to permanently eliminate tumor pathogenic genes. Unfortunately, delivering CRISPR to the GBM in a safe and effective manner is challenging. Herein, a glycosylated and cascade-responsive nanoparticle (GCNP) that can effectively cross the blood-brain barrier (BBB) and activate CRISPR/Cas9-based gene editing only in the GBM is designed.
View Article and Find Full Text PDFAdv Mater
January 2025
School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225009, P. R. China.
Biomimetic calcification is a micro-crystallization process that mimics the natural biomineralization process, where biomacromolecules regulate the formation of inorganic minerals. In this study, it is presented that a protein-assisted biomimetic calcification method for the in situ synthesis of nitrogen-doped metal-organic framework (MOF) materials. A series of unique core-shell structures are created by utilizing proteins as templates and guiding agents in the nucleation step, creating ideal conditions for shell growth.
View Article and Find Full Text PDFSensors (Basel)
December 2024
Institute of Applied Informatics, Automation and Mechatronics, Faculty of Materials Science and Technology in Trnava, Slovak University of Technology in Bratislava, 812 43 Bratislava, Slovakia.
The core of this publication is the design of a system for evaluating the condition of production equipment and machines by monitoring selected parameters of the production process with an additional sensor subsystem. The main positive of the design is the processing of data from the sensor layer using artificial intelligence (AI) and expert systems (ESs) with the use of edge computing (EC). Sensor information is processed directly at the sensor level on the monitored equipment, and the results of the individual subsystems are stored in the form of triggers in a database for use in the predictive maintenance process.
View Article and Find Full Text PDFNutrients
December 2024
Key Laboratory of Pu-er Tea Science, Ministry of Education, Yunnan Agricultural University, Kunming 650201, China.
: Fructus (AOF) is a medicinal and edible resource that holds potential to ameliorate hyperuricemia (HUA), yet its mechanism of action warrants further investigation. : We performed network pharmacology, molecular docking, molecular dynamics simulation, and in vitro experiments to investigate the potential action and mechanism of AOF against HUA. : The results indicate that 48 potential anti-HUA targets for 4 components derived from AOF were excavated and predicted through public databases.
View Article and Find Full Text PDFInt J Mol Sci
December 2024
Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Institute of Gene Biology, Russian Academy of Sciences, 119334 Moscow, Russia.
Duchenne muscular dystrophy (DMD) is a severe X-linked genetic disorder caused by an array of mutations in the dystrophin gene, with the most commonly mutated regions being exons 48-55. One of the several existing approaches to treat DMD is gene therapy, based on alternative splicing and mutant exon skipping. Testing of such therapy requires animal models that carry mutations homologous to those found in human patients.
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