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Targeting PAR1 activation in JAK2V617F-driven philadelphia-negative myeloproliferative neoplasms: Unraveling its role in thrombosis and disease progression.
Neoplasia
March 2025
Department of Genetics, Aziz Sancar Institute of Experimental Medicine, Istanbul University, Istanbul, Türkiye. Electronic address:
Philadelphia chromosome-negative myeloproliferative neoplasms (PhMPNs) are clonal disorders marked by high morbidity and mortality, driven by uncontrolled myeloid proliferation from hematopoietic stem/progenitor cells (HSCs) and associated with a significant risk of thrombosis. This study explored the relationship between JAK2V617F and protease-activated receptor 1 (PAR1) by examining PAR1 expression and activation across various hematopoietic stem/progenitor cell (HSPC) subgroups, assessing their contribution to the hypercoagulable state in PhMPNs. We investigated the effects of thrombin, a PAR1 antagonist (vorapaxar), and a JAK2 inhibitor (ruxolitinib) on PhMPN cells.
View Article and Find Full Text PDFMotion control strategy for robotic arm using deep cascaded feature-enhancement Bayesian broad learning system with motion constraints.
ISA Trans
March 2025
School of Information Science and Technology, Beijing University of Technology, Beijing 100124, China; Beijing Key Laboratory of Computing Intelligence and Intelligent Systems, Beijing 100124, China. Electronic address:
Intelligent control strategies can significantly enhance the efficiency of model parameter adjustment. However, existing intelligent motion control strategies for robotic arms based on the broad learning system lack sufficient accuracy and fail to account for the effects of joint motion limitations on overall control performance. To address the aforementioned challenges, this paper proposes a robotic arm motion control strategy based on a deep cascaded feature-enhanced Bayesian broad learning system with motion constraints (MC-DCBLS).
View Article and Find Full Text PDFDiagnostic tests for tuberculosis infection and predictive indicators of disease progression: utilizing host and pathogen biomarkers to enhance the TB elimination strategies.
Int J Infect Dis
March 2025
Translational Research Unit, National Institute for Infectious Diseases "Lazzaro Spallanzani"- Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Rome, Italy. Electronic address:
Tuberculosis (TB) remains the leading cause of death worldwide from a single infectious disease. An estimated quarter of the world's population, about 2 billion people, has an immune response to Mtb without clinical, microbiological, or radiological signs of TB disease. This condition is known as TB infection (TBI) and carries a lifelong risk of reactivation with 5-10% of individuals eventually developing TB disease during their lifetime.
View Article and Find Full Text PDFDevelopmental decorrelation of local cortical activity through adolescence supports high-dimensional encoding and working memory.
Dev Cogn Neurosci
March 2025
Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, United States; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, United States; Department of Psychology, University of Pittsburgh, Pittsburgh, PA, United States.
Adolescence is a key period for the maturation of cognitive control during which cortical circuitry is refined through processes such as synaptic pruning, but how these refinements modulate local functional dynamics to support cognition remains only partially characterized. Here, we used data from a longitudinal, adolescent cohort (N = 134 individuals ages 10-31 years, N = 202 total sessions) that completed MRI scans at ultra-high field (7 Tesla). We used resting state fMRI data to compute surface-based regional homogeneity (ReHo)-a measure of time-dependent correlations in fMRI activity between a vertex and its immediate neighbors-as an index of local functional connectivity across the cortex.
View Article and Find Full Text PDFCoinfection with bacterial pathogens and genetic modification of PRRSV-2 for suppression of NF-κB and attenuation of proinflammatory responses.
Virology
March 2025
Department of Pathobiology, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, IL, USA. Electronic address:
Porcine reproductive and respiratory syndrome virus (PRRSV) infects pulmonary alveolar macrophages and induces inflammation in the respiratory system. In swine farms, coinfection with PRRSV and bacterial pathogens is common and can result in clinically complicated outcomes, including porcine respiratory disease complex. Coinfection can cause excessive expressions of proinflammatory mediators and may lead to cytokine-storm-like syndrome.
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