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Injectable microspheres filled with copper-containing bioactive glass improve articular cartilage healing by regulating inflammation and recruiting stem cells.
Regen Biomater
December 2024
Orthopedics and Sports Medicine Center, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou 215008, P. R. China.
Osteoarthritis (OA) is a frequent chronic illness in orthopedics that poses a major hazard to patient health. cell therapy is emerging as a therapeutic option, but its efficacy is influenced by both the inflammatory milieu and the amount of stem cells, limiting its use. In this study, we designed a novel injectable porous microsphere (PM) based on microfluidic technology that can support mesenchymal stem cells (MSCs) therapy by combining polylactic-glycolic acid copolymer, kartogenin, polydopamine, stromal cell-derived factor-1, and copper-doped bioactive glass (CuBG).
View Article and Find Full Text PDFPolydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection.
Adv Sci (Weinh)
January 2025
Department of Otolaryngology Head and Neck Surgery, Nanjing Drum Tower Hospital, Jiangsu Provincial Key Medical Discipline, Nanjing University Medical School, Nanjing, 210008, China.
Cisplatin-induced ototoxicity is attributed to the aberrant accumulation of reactive oxygen species (ROS) within the inner ear. Antioxidants represented by α-lipoic acid (ALA) have been demonstrated to scavenge ROS in the cochlea, while effective delivery of these agents in vivo remains a major challenge. Here, a novel polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for controllable is presented ALA delivery and deafness prevention.
View Article and Find Full Text PDFMussel-inspired multi-bioactive microsphere scaffolds for bone defect photothermal therapy.
Mater Today Bio
December 2024
Department of Orthopedics, Shanghai Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Article Synopsis
- - Hydrogel microspheres are viewed as effective scaffolds for bone repair due to their biocompatibility and ability to adapt to irregular defect shapes, but improvements in bioactivity are still needed.
- - The development of multi-bioactive microspheres combines methacrylated silk fibroin with encapsulated magnesium ascorbyl phosphate, promoting angiogenesis and osteogenic differentiation.
- - A coating of polydopamine adds the ability to conform to bone defect shapes and provides photothermal stimulation, enhancing the overall effectiveness of the scaffold in promoting bone healing.
Polydopamine-mediated gold nanoparticle coating strategy and its application in photothermal polymerase chain reaction.
Lab Chip
November 2024
Department of BioNano Technology, Gachon University, Seongnam-si, Gyeonggi-do, Republic of Korea.
Materials with high light-to-heat conversion efficiencies offer valuable strategies for remote heating. These materials find wide applications in photothermal therapy, water distillation, and gene delivery. In this study, we investigated a universal coating method to impart photothermal features to various surfaces.
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