A total of 319 psoriasis patients were treated at the Interdistrict Rehabilitation Center for Skin Diseases. Multiple-modality treatment making use of therapeutic factors of the Sea of Azov (sea water, liman and sea muds, solar or UV irradiation, mineral water) and (in some cases) drugs was employed. The suggested method of differentiated therapy in summer and autumn-winter has brought a manifest therapeutic effect, was conducive to regression of the clinical symptoms, to normalization of concomitant abnormalities of the gastrointestinal tract, liver, hematologic, biochemical, and immunological parameters. Such therapy resulted in prolongation of remissions, shortening of the treatment terms, and a more benign course of the disease, particularly so after repeated courses administered for 2-4 years.

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