AI Article Synopsis
- Cell movement and intercellular signaling happen together during tissue development, but the impact of movement on signaling is not well understood.
- Previous theories suggest that cells moving faster can help synchronize a population of genetic oscillators, but they assume immediate interaction with new neighbors.
- A new study introduces a phase oscillator model showing that there is an optimal movement rate for synchronization and a critical rate above which synchronization fails, highlighting the importance of the timing between movement and signaling recovery for effective communication between cells.
Article Abstract
Cell movement and intercellular signaling occur simultaneously during the development of tissues, but little is known about how movement affects signaling. Previous theoretical studies have shown that faster moving cells favor synchronization across a population of locally coupled genetic oscillators. An important assumption in these studies is that cells can immediately interact with their new neighbors after arriving at a new location. However, intercellular interactions in cellular systems may need some time to become fully established. How movement affects synchronization in this situation has not been examined. Here, we develop a coupled phase oscillator model in which we consider cell movement and the gradual recovery of intercellular coupling experienced by a cell after movement, characterized by a moving rate and a coupling recovery rate, respectively. We find (1) an optimal moving rate for synchronization and (2) a critical moving rate above which achieving synchronization is not possible. These results indicate that the extent to which movement enhances synchrony is limited by a gradual recovery of coupling. These findings suggest that the ratio of time scales of movement and signaling recovery is critical for information transfer between moving cells.
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| http://dx.doi.org/10.1088/1478-3975/9/3/036006 | DOI Listing |
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