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Ivabradine reduces neuropathic pain after spinal cord injury by inhibiting excitatory synaptic transmission in the spinal dorsal horn.
Neurosci Lett
January 2025
Division of Anesthesiology, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi Dori, Chuo-Ku, Niigata City, Niigata 951-8510, Japan. Electronic address:
Spinal cord injuries (SCIs) can lead to severe neuropathic pain and increased risk of myocardial infarction and heart failure; therefore, the use of analgesics against SCI-induced pain should be minimized because of their adverse effects on the cardiovascular system. Ivabradine, a blocker of hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels, is used as a bradycardic agent, but recent studies focused on it as an analgesic agent for peripheral neuropathic pain. However, the analgesic effects of ivabradine on central neuropathic pain, such as SCI-induced pain, have not been examined.
View Article and Find Full Text PDFMicroplastics in the benthic fish from the Canadian St. Lawrence River and Estuary: Occurrence, spatial distribution and ecological risk assessment.
Mar Pollut Bull
January 2025
Institut des sciences de la mer, Université du Québec à Rimouski, Rimouski, Québec G5L 3A1, Canada. Electronic address:
Microplastic contamination in the St. Lawrence River and Estuary (SLRE), Canada, poses potential risks to aquatic species. However, limited understanding of microplastic contamination in benthic fish, potentially more vulnerable than pelagic species, impedes effective risk assessment in this crucial ecosystem.
View Article and Find Full Text PDFCeF-Accelerated surface reconstruction of MoO nanosheets into coral-like CeF/MoO composites enhances the oxygen evolution reaction for efficient water splitting.
J Colloid Interface Sci
January 2025
College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:
Developing efficient and cost-effective rare earth element-based electrocatalysts for water splitting remains a significant challenge. To address this, interface engineering and charge modulation strategies were employed to create a three-dimensional coral-like CeF/MoO heterostructure electrocatalyst, grown in situ on the multistage porous channels of carbonized sugarcane fiber (CSF). Integrating abundant CeF/MoO heterostructure interfaces and numerous oxygen vacancy defects significantly enhanced the catalyst's active sites and molecular activation capabilities.
View Article and Find Full Text PDFDistribution of potentially toxic elements in sediments of the municipal river channel (Balu), Dhaka, Bangladesh: Ecological and health risks assessment.
J Contam Hydrol
January 2025
International Joint Laboratory on Synthetic Biology and Biomass Biorefinery, Biofuels Institute, School of Emergency Management, School of the Environment and Safety Engineering, Jiangsu University, Jiangsu, Zhenjiang 212013, China; Jiangsu Collaborative Innovation Center of Technology and Material of Water Treatment, Suzhou University of Science and Technology, Suzhou 215009, China. Electronic address:
The concern of potential toxic elements (PTEs) contamination in the river ecosystem is growing due to anthropological activity. The contents of seven PTEs in sediments from the Balu River channel were analyzed using atomic absorption spectroscopy (AAS) and an environmental risk model. Several PTEs were found in the sediment at high levels, including zinc (Zn), copper (Cu), arsenic (As), lead (Pb), cadmium (Cd), nickel (Ni), and mercury (Hg), that might pose a risk to human and ecological health.
View Article and Find Full Text PDFMultiple mechanisms of action for an extremely painful venom.
Curr Biol
December 2024
Department of Biology, Indiana University, Bloomington, IN 47405, USA; Gill Institute for Neuroscience, Indiana University, Bloomington, IN 47405, USA; Program in Neuroscience, Indiana University, Bloomington, IN 47405, USA. Electronic address:
Evolutionary arms races can lead to extremely specific and effective defense mechanisms, including venoms that deter predators by targeting nociceptive (pain-sensing) pathways. The venom of velvet ants (Hymenoptera: Mutillidae) is notoriously painful. It has been described as "Explosive and long lasting, you sound insane as you scream.
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