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Impact of dyslipidemia and lipid-lowering therapy with statins in patients with neuroendocrine tumors.
J Neuroendocrinol
December 2024
Endocrinology, Diabetology and Andrology Unit, Department of Clinical Medicine and Surgery, Federico II University of Naples, Naples, Italy.
Dyslipidemia is a potential unfavorable prognostic factor in neuroendocrine tumors (NETs); conversely, statins proved to have antiproliferative effects in NET cell lines and could be a helpful therapeutic strategy for these patients. The main objective of this observational cohort retrospective study is to explore the associations between dyslipidemia and NET progression and evaluate the potential influence of statins in this context. 393 patients with histologically confirmed gastroenteropancreatic or bronchopulmonary NETs from six Italian centres didicated to NET diagnosis and therapy were included.
View Article and Find Full Text PDFExploring the Italian Population's attitudes toward health data sharing for healthcare purpose and scientific research: a cross-sectional study.
J Public Health (Oxf)
December 2024
Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy.
Background: This study aimed to explore the Italian population's knowledge and perceptions regarding health data storage and sharing for treatment and research and to identify factors associated with citizens' attitudes toward data storage and sharing.
Methods: A cross-sectional questionnaire, distributed to 1389 participants, collected sociodemographic information, assessed knowledge and gauged attitudes toward sharing data for treatment and research. Descriptive analyses and logistic regressions were performed to examine the associations between sociodemographic factors and knowledge/attitudes about data storage and sharing.
Low Incidence of Cancer Recorded in the Galapagos Archipelago.
Cancer Rep (Hoboken)
December 2024
Surgical, Medical and Dental Department of Morphological Sciences Related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.
Background: Cancer incidence in the Galapagos archipelago is unknown.
Aim: In 2021, a task force including Ecuadorian and Italian researchers was established to estimate cancer incidence among the 25 244 Galapagos residents.
Methods: Registration covered all malignancies, including malignant melanoma and non-melanoma skin cancers; case recording was based on the International Classification of Diseases for Oncology.
Psychometric properties of the revised quality of nursing diagnosis, interventions, and outcomes instrument: A validation study.
Int J Nurs Knowl
December 2024
Direction of Health Professions, Azienda Socio Sanitaria Territoriale di Cremona, Cremona, Italy.
Aim: The aim of this study was to evaluate the psychometric properties of the revised quality of nursing diagnosis, interventions, and outcomes (Q-DIO R) instrument, designed to measure the quality of nursing documentation, in an Italian healthcare setting.
Methods: The study followed a multi-phase validation process that included translation and cultural adaptation of the tool, expert evaluations to assess content and face validity, and a cross-sectional study to test reliability. Data were collected from nursing documentation in two hospitals in northern Italy, with 389 patient plans analyzed.
The potential of Generative Pre-trained Transformer 4 (GPT-4) to analyse medical notes in three different languages: a retrospective model-evaluation study.
Lancet Digit Health
January 2025
Department of Biomedical Informatics, Medical School, Harvard University, Boston, MA, USA. Electronic address:
Background: Patient notes contain substantial information but are difficult for computers to analyse due to their unstructured format. Large-language models (LLMs), such as Generative Pre-trained Transformer 4 (GPT-4), have changed our ability to process text, but we do not know how effectively they handle medical notes. We aimed to assess the ability of GPT-4 to answer predefined questions after reading medical notes in three different languages.
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