AI Article Synopsis
- Signaling through the T cell antigen receptor (TCR) plays a crucial role in the development and selection of thymocytes, particularly in the CD4(+)CD8(+) double-positive stage.
- A new protein called Tespa1 has been identified as essential for the positive selection of these thymocytes, as Tespa1(-/-) mice showed reduced numbers of mature CD4(+) and CD8(+) T cells due to impaired development.
- Tespa1 interacts with key TCR signaling proteins, and its absence leads to weakened TCR signaling pathways, highlighting its importance in T cell maturation and selection.
Article Abstract
Signaling via the T cell antigen receptor (TCR) during the CD4(+)CD8(+) double-positive developmental stage determines thymocyte selection and lineage commitment. Here we describe a previously uncharacterized T cell-expressed protein, Tespa1, with critical functions during the positive selection of thymocytes. Tespa1(-/-) mice had fewer mature thymic CD4(+) and CD8(+) T cells, which reflected impaired thymocyte development. Tespa1 associated with the TCR signaling components PLC-γ1 and Grb2, and Tespa1 deficiency resulted in attenuated TCR signaling, as reflected by defective activation of the Erk-AP-1 and Ca(2+)-NFAT pathways. Our findings demonstrate that Tespa1 is a component of the TCR signalosome and is essential for T cell selection and maturation through the regulation of TCR signaling during T cell development.
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| http://dx.doi.org/10.1038/ni.2301 | DOI Listing |
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