Novel (4-(4-iodophenyl)-thiazol-2-yl)hydrazine derivatives were assayed for their in vitro anti-Candida activity, compared to topical and systemic antifungal drugs, against twenty-seven clinical isolates. The presence of aliphatic chains or specific heteroaromatic rings on hydrazone moiety at position C2 and a 4-iodophenyl at C4 of the thiazole ring gave a promising inhibitory activity especially against Candida albicans and Candida krusei. The most active compounds have been also evaluated for their cytotoxicity and in association with clotrimazole for anti-Candida activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ejmech.2012.04.006 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of Mn(II) and Co(II) on Anti- Metabolite Production by sp. an Endophyte Isolated from (Plantaginaceae).
Pharmaceuticals (Basel)
December 2024
Chemistry Postgraduate Program, Federal Institute of Science Education and Technology of Maranhão, São Luís 65030-005, Brazil.
: This study evaluates the effect of Mn(II) and Co(II) ions on the production of anti- metabolites by the endophytic fungus Aspergillus sp., isolated from . The objective was to identify metal-induced secondary metabolites with antifungal potential against drug-resistant species.
View Article and Find Full Text PDFNovel Isoxazole-Based Antifungal Drug Candidates.
Int J Mol Sci
December 2024
Department of Organic Chemistry and Drug Technology, Faculty of Pharmacy, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Microbiological communities have a significant impact on health and disease. are ubiquitous fungal pathogens that colonize the mucosal surfaces of the genital, urinary, respiratory, and gastrointestinal tracts, as well as the oral cavity. If the immune system is inadequate, then infections may pose a significant threat.
View Article and Find Full Text PDFEllagic Acid Potentiates the Inhibitory Effects of Fluconazole Against .
Antibiotics (Basel)
December 2024
Centro de Ciências da Saúde, Universidade Federal do Maranhão, São Luís 65080-805, MA, Brazil.
: Antifungal resistance to azoles, coupled with the increasing prevalence of infections, represents a significant public health challenge and has driven the search for new natural compounds that can act as alternatives or adjuvants to the current antifungals. Ellagic acid (EA) has demonstrated antifungal activity; however, its effects are not fully understood. In this study, we investigated the in vitro anti- activity of EA and its ability to potentiate the effects of fluconazole (FLZ) on : The Minimum Inhibitory Concentration (MIC) of EA was determined by broth microdilution and its interaction with FLZ was assessed using a checkerboard assay.
View Article and Find Full Text PDFAntimicrobial Effect of Formononetin Against the Periodental Pathogens Enterococcus faecalis and Candida albicans.
Recent Pat Biotechnol
December 2024
School of Dentistry, Lorestan University of Medical Sciences, Khorramabad, Iran.
Background: Among the bioactive isoflavones identified from different plants is formononetin. Formononetin's antioxidant, anti-inflammatory, and anti-cancer qualities have all received a lot of attention lately. The goal of the current investigation was to examine formononetin's antifungal and antibacterial activity against Candida albicans and Enterococcus faecalis in vitro, respectively.
View Article and Find Full Text PDFChemometrics of the Seasonal Influence on Chemical Composition, Yield, Antioxidant Capacity, and Anti-Candida Activity of Alpinia nutans Essential Oil Growing in the Brazilian Amazon Region.
Chem Biodivers
December 2024
Laboratório de Química dos Produtos Naturais, Universidade do Estado do Pará, Belém, Pará, Brazil.
Alpinia nutans (L.) Roscoe (Zingiberaceae) is used in folk medicine as an antiviral, anti-inflammatory, and antioxidant. This study aimed to evaluate the seasonality effects on the yield, chemical composition, antioxidant capacity, and anti-Candida activity of the A.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!