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[Expression and significance of the NK cell receptors in primary hepatocellular carcinoma and paracancerous tissues]. | LitMetric

AI Article Synopsis

  • The study aimed to examine the presence of activating and inhibitory receptors on NK cells in primary liver cancer tissues and their adjacent areas to understand their roles in liver cancer development.
  • It involved analyzing NK cell activity and receptor expression using flow cytometry and immunohistochemistry on samples from 52 liver cancer patients.
  • Findings showed that liver cancer tissues had fewer NK cells and lower activating receptor levels, while inhibitory receptor levels were higher, suggesting that these changes in NK cell characteristics may relate to the progress and occurrence of primary hepatocellular carcinoma.

Article Abstract

Aim: To investigate the expression of the activating and inhibitory receptors on the surface of NK cells of primary hepatocellular carcinoma and its adjacent tissues, and the relationship between these two receptors and occurrence and development of primary liver cancer was analyzed.

Methods: The number and activity of the NK cells, the expression of the activating and the inhibitory receptors on the surface of those cells were detected flow cytometry and immunohistochemistry, which were obtained from 52 cases of primary hepatocellular carcinoma and its adjacent tissues. The relative analysis was done between those results and clinical relative factors.

Results: In the tissues of primary hepacellular carcinoma, the number of NK cells is lower than that in the adjacent tissues obviously (P<0.01); the expression of activating receptors, NKG2D and NKP44, is also lower than that in the adjacent tissues obviously (P<0.05); the expression of inhibitory receptors, CD158b and CD159a, is significantly higher than that in the adjacent tissues (P<0.05). A negative correlation was found between the expression of NKG2D, NKP30 and NKP44 and the clinical stage of the liver cancer. The expression of NKG2D, NKP30 and NKP44 was higher in patients with early and middle stages (P<0.05). The content of the inhibitory receptors of NK cells, CD158b and CD159a, is higher in tissues from patients with advanced cancer stage (P<0.05). That's also correlated with the level of AFP and the HBsAg. There is no significant statistical difference between the expression of NK receptors and the distant metastasis, tumor differentiation as well as the tumor size (P>0.05).

Conclusion: The decrease of NK cell numbers and the activating NK cell receptors and the increase of the inhibitory receptors would be relevant to the incidence of primary hepacellular carcinoma.

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