The aqueous and alcoholic extracts of Leucas aspera were investigated for their action on experimental inflammation and on mast cell degranuatlion. Both the extracts exhibited significant antiinflammatory action of acute and chronic inflammation. The mast cell drgranulation induced by proprancolol and Carbachol was effectively prevented by pretreatment with Leucas aspera extracts.
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Front Pharmacol
May 2024
School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India.
Background: Snakebite is a neglected tropical disease that affects millions of people worldwide. Developing effective treatments can make a significant contribution to global health efforts and public health initiatives. To reduce mortality due to snakebite, there is an immediate need to explore novel and effective treatment methodologies.
View Article and Find Full Text PDFJ Basic Microbiol
July 2024
Department of Botany, School of Applied Sciences, Centurion University of Technology and Management, Bhubaneswar, Odisha, India.
Dermatophytosis is a cutaneous infection that is able to degrade the keratinized tissues of the animal/human body, like skin, nails, and hair, causing chronic or subacute infection with the contact of some specific fungal strains. Trichophyton mentagrophytes are the most potential fungal pathogen causing dermatophytoses. The present study focuses on computationally based in silico antifungal activity of selected phytocompounds of Leucas aspera (Willd.
View Article and Find Full Text PDFBioTechnologia (Pozn)
March 2024
B.S. Abdur Rahman Crescent Institute of Science and Technology, Vandalur, Tamil Nadu, India.
Breast cancer is the most recurrently identified and one of women's prominent causes of death. Currently, researchers have turned their focus on natural chemicals from synthetic chemicals due to their environmental, economic, and health benefits. Considering this, the medicinal plant was chosen for the current study.
View Article and Find Full Text PDFNat Prod Res
January 2024
Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India.
A phytochemical investigation of involved the isolation of flavones and steroids, along with triterpenoids. The identified chemical constituents were characterized as baicalein, baicalein-7-O-β-D-glucuronide, lup-20(29)-ene-3α,23-diol, β-sitosterol, and stigmasterol. Notably, baicalein (4) and baicalein-7-O-β-D-glucuronide (5) demonstrated significant antimicrobial activity at a low minimum inhibitory concentration against , , and .
View Article and Find Full Text PDFACS Omega
March 2023
Department of Applied Chemistry, School of Applied Natural Sciences, Adama Science and Technology University, P.O. Box: 1888, Adama 1888, Ethiopia.
The cost-effective novel Ag-doped (1-7%) (CuO-CuO)Cu (C3) heterostructured nanocomposites are successfully synthesized by the facile solution combustion process using the extract as a green fuel. The structural properties of fabricated nanocomposites were well-characterized by specific spectral techniques for enhanced electrochemical sensor detection, antibacterial activities, and sunlight-driven photocatalytic dye decoloration studies. The existence of Ag ions has been confirmed by the appearance of two peaks of Ag 3d (367.
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