Berberis asiatica Roxb. Ex. Dc., non Griff. Belongs to the family berberidaceae commonly occurring in the dry outer Himalaya, Assam etc. Roots along with stem bark s a reputed drug in Ayurvedic medicine contain several alkaloids. 50% Ethaolnic extract of roots reported to posses anti-cancer activity. The present study examines the antitumour effect of ethanolic root extract (BRE) against Dalton's lymphoma ascites tumour cells and solid tumour in swiss albino mice, A significant enhancement of mean survival time of BRE treated tumour bearing mice was found. Oral administration of BRE reduced the solid tumour induced by DLE and restored the altered haematological parameters to normal.
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Cureus
August 2024
Department of Pharmacology, Krishna Institute of Medical Sciences, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Introduction Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance, impaired insulin secretion, and beta cell dysfunction, often leading to chronic hyperglycemia and associated complications. () and () are ancient medicinal plants with a reputation for having potential therapeutic effects in diabetes management. The purpose of this study was to look into how body weight (BW) was affected in streptozotocin-nicotinamide (STZ-NIC) induced T2DM in Wistar rats by , , and their polyherbal combination (PHC).
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August 2024
Department of Pharmacology, Krishna Vishwa Vidyapeeth (Deemed to be University), Karad, IND.
Introduction Type 2 diabetes mellitus (T2DM) is a chronic metabolic disorder characterized by insulin resistance and hyperglycemia, leading to complications such as dyslipidemia, which increases cardiovascular risks. Current treatments for dyslipidemia often have undesirable side effects. This study aims to evaluate the effects of (), (), and their combination in the ratio of 1:1 on the lipid profile in T2DM-induced Wistar rats.
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July 2024
Department of Pharmacology, Krishna Vishwa Vidyapeeth (Deemed to be University), Satara, IND.
Background and aim Diabetes is a chronic metabolic disorder characterized by elevated blood glucose levels. Although current antidiabetic drugs are highly effective, they are associated with various adverse drug reactions, including life-threatening hypoglycemia, skin rashes, and gastrointestinal intolerance, in addition to being costly. This animal-based experimental study aims to develop a herbal alternative or adjuvant to current antidiabetic drugs using () and (), which could potentially have fewer adverse drug reactions and reduce the required dose of existing antidiabetic medications.
View Article and Find Full Text PDFNat Prod Res
February 2024
Pharmacognosy Division, CSIR-National Botanical Research Institute, Lucknow, India.
The genus has high significance in Indian and other traditional systems of medicine due to the presence of -quinoline alkaloids. This study was conducted to record the metabolic variation in eight spp. collected from the Western Himalayan region.
View Article and Find Full Text PDFEnviron Manage
January 2025
School of Environmental Sciences, Jawaharlal Nehru University, New Delhi, 110067, India.
Plant invasion is a leading threat to biodiversity, ecosystem services and human wellbeing worldwide. In the central Himalayas intentionally or accidentally introduced invasive alien plant species (IAPS) facilitate their own establishment and spread, which is altering forest structure, vegetation composition, species diversity and livelihood. To understand the perception and awareness amongst local communities about invasive alien and native plants and its effect on local livelihood, a questionnaire-based study was conducted in 10 villages of Nainital district, Uttarakhand, India.
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