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The management of Wilms' tumor emerging of the outstanding clinical trials undertaken in the developed world in the last four decades has led to excellent longterm outcomes. The scenario in developing country like India is different; late presentation with massive tumors and advanced stage, lacunae in staging, nonavailability of pediatric medical oncologists and poor follow-ups are common. A comprehensive summary of available therapeutic modalities is provided here along with clear roadmaps of management of Wilms' tumor as per Société Internationale d'Oncologie Pédiatrique (SIOP) and National Wilms' Tumor Study Group/Children's Oncology Group (NWTSG/COG) protocols in simple tabulated form.
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http://dx.doi.org/10.1007/s12098-012-0747-3 | DOI Listing |
Nat Commun
March 2025
Department of Epigenetics, Van Andel Institute, Grand Rapids, MI, 49503, USA.
Recurrent gain-of-function mutations in the histone reader protein ENL have been identified in Wilms tumor, the most prevalent pediatric kidney cancer. However, their pathological significance in kidney development and tumorigenesis in vivo remains elusive. Here, we generate mouse models mimicking ENL tumor (ENL) mutations and show that heterozygous mutant expression in Six2 nephrogenic or Foxd1 stromal lineages leads to severe, lineage-specific kidney defects, both resulting in neonatal lethality.
View Article and Find Full Text PDFPediatr Blood Cancer
March 2025
Department of Paediatric Surgery, KK Women's and Children's Hospital, Singapore, Singapore.
Purpose: To profile the surgical management of pediatric renal tumors rendered in low- and middle-income countries (LMICs) of the Asia Pacific region, which are not currently affiliated to any pediatric renal tumor cooperative group.
Methods: An online survey was conducted among surgeons and urologists identified through the St. Jude Global Online Community Asia Pacific Pediatric Surgical Collaborations Group and participants of the St.
Pediatr Blood Cancer
March 2025
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
Background And Aim: Current pediatric renal tumor treatment protocols allow for nephron-sparing surgery (NSS) for unilateral disease only under strict conditions. Oncological guidelines do not account for surgical feasibility, however, possibly reducing the utilization of NSS. To potentially change this, a definition of surgical feasibility is required.
View Article and Find Full Text PDFEur Radiol
March 2025
Department of Radiology, Hacettepe University School of Medicine, Ankara, Türkiye.
Eur Radiol
March 2025
Affiliated Hospital of Jining Medical University, 89 Guhuai Road, Jining, 272007, China.
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