AI Article Synopsis
- Cycling eukaryotic cells quickly rebuild their nuclear envelope and internal structures after cell division (mitosis).
- Recent studies using an anti-nucleosome antibody showed that the surface of chromatin in both interphase and mitotic cells has a distinct structure, which could be important for nuclear reformation after mitosis.
- The study found that the lipid phosphatidylserine is present at the chromatin surface throughout the cell cycle and may help recruit the endoplasmic reticulum (ER) to rebuild the nuclear envelope.
Article Abstract
Cycling eukaryotic cells rapidly re-establish the nuclear envelope and internal architecture following mitosis. Studies with a specific anti-nucleosome antibody recently demonstrated that the surface ("epichromatin") of interphase and mitotic chromatin possesses a unique and conserved conformation, suggesting a role in postmitotic nuclear reformation. Here we present evidence showing that the anionic glycerophospholipid phosphatidylserine is specifically located in epichromatin throughout the cell cycle and is associated with nucleosome core histones. This suggests that chromatin bound phosphatidylserine may function as a nucleation site for the binding of ER and re-establishment of the nuclear envelope.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3383575 | PMC |
| http://dx.doi.org/10.4161/nucl.19662 | DOI Listing |
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