Sex-chromosome dosage compensation requires selective identification of X chromatin. How this occurs is not fully understood. We show that small interfering RNA (siRNA) mutations enhance the lethality of Drosophila males deficient in X recognition and partially rescue females that inappropriately dosage-compensate. Our findings are consistent with a role for siRNA in selective recognition of X chromatin.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3389965 | PMC |
| http://dx.doi.org/10.1534/genetics.112.140236 | DOI Listing |
Publication Analysis
Top Keywords
role sirna
8
dosage compensation
8
sirna x-chromosome
4
x-chromosome dosage
4
compensation drosophila
4
drosophila melanogaster
4
melanogaster sex-chromosome
4
sex-chromosome dosage
4
compensation requires
4
requires selective
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!