Aim: To investigate 5-hydroxytryptamine (5-HT) function and 5-HT receptor 2A (5-HT2A) mRNA expression in the formation of lens-induced myopia (LIM).
Methods: Lens-induced myopia construction method was applied to generate myopia on guinea pig right eye (LIM eye).
Results: LIM eyes formed significant myopia with longer axial length. 5-HT level in retina, choroids and sclera from LIM eyes was significantly higher than that in control group. 5-HT2A mRNA expression was also significantly up-regulated.
Conclusion: Refraction lens could induce myopia in guinea pig and 5-HT may play an important role in the formation of myopia by binding with 5-HT2A receptor.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3340756 | PMC |
| http://dx.doi.org/10.3980/j.issn.2222-3959.2010.04.05 | DOI Listing |
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