Evaluation of detemir in diabetic cats managed with a protocol for intensive blood glucose control.

J Feline Med Surg

Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg.

Published: August 2012

The aim of this study was to report outcomes using detemir and a protocol aimed at intensive blood glucose control with home monitoring in diabetic cats, and to compare the results with a previous study using the same protocol with glargine. Eighteen cats diagnosed with diabetes and previously treated with other insulins were included in the study. Data was provided by owners who joined the online German Diabetes-Katzen Forum. The overall remission rate was 67%. For cats that began the protocol before or after 6 months of diagnosis, remission rates were 81% and 42%, respectively (P = 0.14). No significant differences were identified between the outcomes for the glargine and detemir studies, with the exception of three possibly interrelated factors: a slightly older median age of the detemir cohort at diabetes diagnosis, a higher rate of chronic renal disease in the detemir cohort and lower maximal dose for insulin detemir.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11104196PMC
http://dx.doi.org/10.1177/1098612X12446211DOI Listing

Publication Analysis

Top Keywords

diabetic cats
8
intensive blood
8
blood glucose
8
glucose control
8
detemir cohort
8
detemir
5
evaluation detemir
4
detemir diabetic
4
cats
4
cats managed
4

Similar Publications

Exploring Tetraselmis chui microbiomes-functional metagenomics for novel catalases and superoxide dismutases.

Appl Microbiol Biotechnol

January 2025

Department of Microbiology and Biotechnology, Institute of Plant Science and Microbiology, University of Hamburg, Ohnhorststr.18, 22609, Hamburg, Germany.

The focus on microalgae for applications in several fields, e.g. resources for biofuel, the food industry, cosmetics, nutraceuticals, biotechnology, and healthcare, has gained increasing attention over the last decades.

View Article and Find Full Text PDF

The FreeStyle Libre (Abbott) is a human continuous glucose monitor sensor that has been used to monitor glucose concentrations in dogs and cats with diabetes. This sensor and other similar continuous glucose monitoring sensors are increasingly popular in veterinary medicine, specifically for management of diabetes mellitus. The sensor decreases veterinary visits and reduces the stress (and expense) of multiple blood sample collections needed to produce glucose curves.

View Article and Find Full Text PDF

Objectives: The aim of this study was to describe signalment, clinicopathological findings, management practices and the occurrence of comorbidities in feline diabetes mellitus (DM) in Germany.

Methods: This was a cross-sectional study using questionnaires and laboratory submissions to a commercial laboratory, Antech Lab Germany, between May 2021 and July 2022. Inclusion criteria were diagnosis of DM by the attending veterinarian and submission of a completed questionnaire besides blood samples.

View Article and Find Full Text PDF

Like humans, cats have a strong relationship between decreasing insulin sensitivity and the development of diabetes with obesity. However, the underlying molecular mechanisms of impaired insulin secretion and signaling in cats remain largely unknown. A total of 54 client-owned nondiabetic lean ( = 15), overweight ( = 15), and diabetic ( = 24) cats were included in the study.

View Article and Find Full Text PDF

Clinical and biochemical abnormalities in a feline model of GM2 activator deficiency.

Mol Genet Metab

January 2025

Scott-Ritchey Research Center, College of Veterinary Medicine, Auburn University, AL 36849, United States of America; Department of Anatomy, Physiology & Pharmacology, College of Veterinary Medicine, Auburn University, AL 36849, United States of America. Electronic address:

Though it has no catalytic activity toward GM2 ganglioside, the GM2 activator protein (GM2A) is essential for ganglioside hydrolysis by facilitating the action of lysosomal ß-N-acetylhexosaminidase. GM2A deficiency results in death in early childhood due to rapid central nervous system deterioration similar to the related GM2 gangliosidoses, Tay-Sachs disease and Sandhoff disease. This manuscript further characterizes a feline model of GM2A deficiency with a focus on clinical and biochemical parameters that may be useful as benchmarks for translational therapeutic research.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!