Objectives: The aim of the study was to clinically and histologically evaluate the healing of human intrabony defects treated with open flap surgery (OFD) and application of a new, resorbable, fully synthetic, unsintered, nanocrystalline, phase-pure hydroxyapatite (nano-HA).
Materials And Methods: Six patients, each of them displaying very advanced intrabony defects around teeth scheduled for extraction due to advanced chronic periodontitis and further prosthodontic considerations, were included in the study. Following local anaesthesia, mucoperiosteal flaps were reflected; the granulation tissue was removed, and the roots were meticulously debrided by hand and ultrasonic instruments. A notch was placed at the most apical extent of the calculus present on the root surface or at the most apical part of the defect (if no calculus was present) in order to serve as a reference for the histological evaluation. Following defect fill with nano-HA, the flaps were sutured by means of mattress sutures to allow primary intention healing. At 7 months after regenerative surgery, the teeth were extracted together with some of their surrounding soft and hard tissues and processed for histological analysis.
Results: The postoperative healing was uneventful in all cases. At 7 months following surgery, mean PPD reduction and mean CAL gain measured 4.0 ± 0.8 and 2.5 ± 0.8 mm, respectively. The histological analysis revealed a healing predominantly characterized by epithelial downgrowth. Limited formation of new cementum with inserting connective tissue fibers and bone regeneration occurred in three out of the six biopsies (i.e. 0-0.86 and 0-1.33 mm, respectively). Complete resorption of the nano-HA was found in four out of the six biopsies. A few remnants of the graft particles (either surrounded by newly formed mineralized tissue or encapsulated in connective tissue) were found in two out of the six biopsies.
Conclusion: Within their limits, the present results indicate that nano-HA has limited potential to promote periodontal regeneration in human intrabony defects.
Clinical Relevance: The clinical outcomes obtained following surgery with OFD + nano-HA may not reflect true periodontal regeneration.
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| http://dx.doi.org/10.1007/s00784-012-0739-8 | DOI Listing |
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View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate the effectiveness of combining enamel matrix derivatives (EMD) with bone substitutes (BG) in treating periodontal defects compared to using bone substitutes alone.
- Researchers analyzed data from 9 randomized controlled trials with a minimum follow-up of 6 months, focusing on intrabony and furcation defects.
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CALCIUM PHOSPHATE GRAFTS COMBINED WITH GUIDED TISSUE REGENERATION IN THE TREATMENT OF PERIODONTAL BONY DEFECTS- A SYSTEMATIC REVIEW AND META-ANALYSIS.
J Evid Based Dent Pract
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Assistant Professor, Department of Restorative Dentistry, Maurice H. Kornberg School of Dentistry, Temple University, Philadelphia, PA.
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