AI Article Synopsis
- A study diagnosed 191 patients with DSM-IV Bipolar Disorder I or II, examining sociodemographic and clinical characteristics, including comorbidities and neuroticism, at intake and follow-up.
- Approximately 74% of patients had a positive family history (FH) of mood disorders or alcoholism, with 55% related to mood disorders and 36% to alcoholism.
- Patients with a positive FH of both mood disorders and alcoholism had a significantly higher chance (odds ratio of 4.8) of developing anxiety disorders, indicating that family history influences the bipolar patients' mental health course and comorbidities.
Article Abstract
We diagnosed 191 secondary-care outpatients and inpatients with DSM-IV BD I or II. Sociodemographic and clinical characteristics, including axis I and II comorbidity, neuroticism, and prospective life-chart were evaluated at intake and at 6 and 18 months. The family history (FH) of mood disorders, alcoholism, or any major psychiatric disorders among first-degree relatives was investigated in a semistructured interview. Most (74%) patients had some positive FH; 55% of mood disorder, 36% of alcoholism. Positive FH was associated with psychiatric comorbidity and depressive course in the proband. Based on a multinomial logistic regression model, patients with an FH of mood disorder and alcoholism had an odds ratio of 4.8 (p = 0.001) for having an anxiety disorder. Overall, the first-degree relatives of patients with BD have multiple types of mental disorders, which correlate with bipolar patients' course of illness and psychiatric comorbidity. The strongest associations are between FH of mood disorders and presence of comorbid anxiety disorders.
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| http://dx.doi.org/10.1097/NMD.0b013e3182531f2e | DOI Listing |
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