AI Article Synopsis
- The study examined 518 patients with oral lichen planus (OLP) in eastern China, revealing a significant female majority (353 females vs. 165 males) and an average diagnosis age of 46.3 years.
- Approximately 87.8% of patients had lesions on the buccal mucosa, with a near-even split between white lichen (52.3%) and red lichen (47.7%).
- Importantly, around 1% of the patients developed oral cancer, predominantly affecting non-smoking, non-drinking females, indicating OLP's potential malignancy risk.
Article Abstract
Objective: To investigate the epidemiological and clinical characteristics of a relatively large cohort of patients with oral lichen planus (OLP) from eastern China.
Study Design: A total of 518 patients with histologically confirmed OLP in a long-term follow-up period (6 months-21.5 years) were retrospectively reviewed in our clinic.
Results: Of the 518 patients, 353 females and 165 males were identified. The average age at diagnosis was 46.3 years (range 9-81 years) with the buccal mucosa being the most common site (87.8%). At initial presentation, white lichen and red lichen was seen in 52.3% and 47.7% patients, respectively. Of these, 5 (0.96%) patients previously diagnosed clinically and histopathologically as OLP developed oral cancer. All of them were the females with no a history of smoking or alcohol use.
Conclusions: Clinical features of eastern Chinese OLP patients were elucidated. Notably, approximately 1% of OLP developed into cancer, which provides further evidence of potentially malignant nature of OLP.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3505714 | PMC |
| http://dx.doi.org/10.4317/medoral.17778 | DOI Listing |
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