AI Article Synopsis
- A series of alkyl α/β-(1→6)-diglucopyranosides were created and tested for their ability to kill cancer cells from different types, including HL-60 and MCF-7.
- The menthyl derivatives of these diglucopyranosides showed strong cytotoxic effects with IC(50) values ranging from 6 to 16 μM.
- Specifically, one derivative, menthyl β-(1→6)-diglucopyranoside, triggered apoptosis in leukemia cells by activating multiple caspases, which involves cytochrome c release and changes in key protein levels related to cell death.
Article Abstract
A series of alkyl α/β-(1→6)-diglucopyranosides 1-12 were synthesized and assessed for cytotoxicity against HL-60, U937, Molt-3 and MCF-7 cancer cell lines. The menthyl derivatives displayed strong cytotoxic properties showing IC(50) values between 6 and 16 μM. Furthermore, we demonstrated that the selected synthetic (+)-menthyl β-(1→6)-diglucopyranoside 5 induces apoptotic cell death in human leukemia cells through a mechanism that involves activation of multiple caspases. Cell death was completely prevented by the non-specific caspase inhibitor z-VAD-fmk and found to be associated with the release of cytochrome c, an increase in the expression of Bax levels and a decrease in the generation of reactive oxygen species.
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| http://dx.doi.org/10.1016/j.bmcl.2012.04.035 | DOI Listing |
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