Neurodegeneration is the underlying cause of a vast majority of neurological disorders and often a result of brain trauma, stroke, or neurotoxic insult. Here we describe a simple method for labeling degenerating neurons in unfixed brain tissue samples. This method could provide a new avenue for identifying and harvesting degenerative neurons from unfixed brain tissues for subsequent molecular analyses.

Download full-text PDF

Source
http://dx.doi.org/10.1016/j.jneumeth.2012.04.012DOI Listing

Publication Analysis

Top Keywords

neurons unfixed
12
unfixed brain
12
degenerative neurons
8
brain tissue
8
tissue samples
8
one-step labeling
4
labeling degenerative
4
brain
4
samples fluoro-jade
4
fluoro-jade neurodegeneration
4

Similar Publications

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!