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The Intra-Articular Delivery of a Low-Dose Adeno-Associated Virus-IL-1 Receptor Antagonist Vector Alleviates the Progress of Arthritis in an Osteoarthritis Rat Model.
Pharmaceutics
November 2024
Chengdu Origen Biotechnology Co., Ltd., Chengdu 610036, China.
Interleukin-1 (IL-1) is a pivotal mediator in the pathological progression of osteoarthritis (OA), playing a central role in disease progression. However, the rapid clearance of IL-1 receptor antagonist (IL-1Ra) from the joints may hinder the efficacy of intra-articular IL-1Ra injections in reducing OA-associated pain or cartilage degradation. Sustaining sufficient levels of IL-1Ra within the joints via adeno-associated virus (AAV)-mediated gene therapy presents a promising therapeutic strategy for OA.
View Article and Find Full Text PDFOptimization of γ-Aminobutyric Acid Production in Brown Rice via Prolonged Seed Priming.
Plants (Basel)
December 2024
Fujian Laboratory for Rice Germplasm Innovation and Molecular Breeding, Biotechnology Research Institute, Institute of Crop Sciences, Fujian Academy of Agricultural Sciences, Fuzhou 350001, China.
Germinated whole seeds possess elevated levels of bioactive nutrients; however, their application is hindered by several constraints. The germination process is typically time-consuming, and germinated seeds present challenges in terms of storage and transportation compared to dry seeds. This study introduces a novel processing method for rice, termed prolonged priming (PLP), aiming to combine the benefits of germinated and dry seeds.
View Article and Find Full Text PDFGA3-Induced Expression Enhances Cell Wall Remodeling and Plant Height in Tomatoes.
Plants (Basel)
December 2024
College of Horticulture, Shenyang Agricultural University, Shenyang 110866, China.
Plant height represents a pivotal agronomic trait for the genetic enhancement of crops. The plant cell wall, being a dynamic entity, is crucial in determining plant stature; however, the regulatory mechanisms underlying cell wall remodeling remain inadequately elucidated. This study demonstrates that the application of gibberellin 3 (GA3) enhances both plant height and cell wall remodeling in tomato () plants.
View Article and Find Full Text PDFProtective Effects of Cereal-Based Fermented Beverages Against 5-Fluorouracil-Induced Intestinal Damage in Mice.
Nutrients
December 2024
Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China.
Background: 5-Fluorouracil (5-FU) is a common chemotherapeutic medication used to treat cancer. However, the intestinal tract may sustain oxidative damage as a result.
Objectives: The purpose of this study was to clarify the underlying molecular mechanisms and examine the preventive benefits of cereal-based fermented drinks (CFBs) against intestinal injury in mice caused by 5-FU.
Dietary N-6 Polyunsaturated Fatty Acid Intake and Brain Health in Middle-Aged and Elderly Adults.
Nutrients
December 2024
School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Background: Dietary intake of polyunsaturated fatty acids (PUFA) plays a significant role in the onset and progression of neurodegenerative diseases. Since the neuroprotective effects of n-3 PUFA have been widely validated, the role of n-6 PUFA remains debated, with their underlying mechanisms still not fully understood.
Methods: In this study, 169,295 participants from the UK Biobank were included to analyze the associations between dietary n-6 PUFA intake and neurodegenerative diseases using Cox regression models with full adjustments for potential confounders.
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