The Ocean, which is called the "mother of origin of life," is also the source of structurally unique natural products that are mainly accumulated in living organisms. Cyanobacteria are photosynthetic prokaryotes used as food by humans. They are excellent source of vitamins and proteins vital for life. Several of these compounds show pharmacological activities and are helpful for the invention and discovery of bioactive compounds, primarily for deadly diseases like cancer, acquired immunodeficiency syndrome (AIDS), arthritis, and so forth, while other compounds have been developed as analgesics or to treat inflammation, and so forth. They produce a large variety of bioactive compounds, including substances with anticancer and antiviral activity, UV protectants, specific inhibitors of enzymes, and potent hepatotoxins and neurotoxins. Many cyanobacteria produce compounds with potent biological activities. This paper aims to showcase the structural diversity of marine cyanobacterial secondary metabolites with a comprehensive coverage of alkaloids and other applications of cyanobacteria.
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http://dx.doi.org/10.1100/2012/179782 | DOI Listing |
Nat Prod Res
January 2025
Department of Nanotechnology and Advanced Materials, Mersin University, Mersin, Turkey.
Propolis, a natural product with remarkable therapeutic potential, has gained attention for its antimicrobial, antioxidant, and anti-inflammatory properties. In this study, propolis samples from Sarıyaprak, Kovanağzı, and Çemikari in Pervari, Siirt province, were analysed comprehensively. The evaluation included wax composition, DPPH and FRAP assays, total phenolic and flavonoid content, and pollen analysis.
View Article and Find Full Text PDFChemistry
January 2025
VIT University, Materials Chemistry Division, School of Advanced Sciences, VIT University, 632014, Vellore, INDIA.
Amidines are a vital class of bioactive compounds and often necessitate multiple components for their synthesis. Therefore, exploring efficient and sustainable methodologies for their synthesis is indispensable. Herein, we disclose an alternative and greener method for synthesizing an unexplored new class of amidines through the photochemical synergistic effect of copper/nitroxyl radical catalysis.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Nankai University, College of Chemistry, 94 Weijin Road, 300071, Tianjin, CHINA.
Cyclopropanes are prevalent in natural products, pharmaceuticals, and bioactive compounds, functioning as a significant structural motif. Although a series of methods have been developed for the construction of the cyclopropane skeleton, the development of a direct and efficient strategy for the rapid synthesis of cyclopropanes from bench-stable starting materials with a broad substrate scope and functional group tolerance remains challenging and highly desirable. Herein, we present an electrochemical method for the direct cyclopropanation of unactivated alkenes using active methylene compounds.
View Article and Find Full Text PDFChem Biodivers
January 2025
Kunming Institute of Botany Chinese Academy of Sciences, Key laboratory of economic plants and biotechnology, 132# Lanhei Road, Heilongtan, Kunming, Yunnan, China, 650201, Kunming, CHINA.
Mesua ferrea L. is used in Ayurvedic and Thai medicine for treating various diseases, including diabetes. This study aimed to isolate and identify the bioactive constituents from M.
View Article and Find Full Text PDFMol Divers
January 2025
School of Nuclear Technology and Chemistry & Biology, Hubei University of Science and Technology, Xianning, 437100, China.
A series of new arecoline derivatives containing amino acid fragments were synthesized, and their fungicidal activities were investigated. All synthesized compounds were characterized by H NMR, CNMR, and HRMS. Preliminary bioactivity assays demonstrated that Compounds 3k, 3n, 3p, 3q, 3r, and 3s exhibited significant antifungal activity against Botryosphaeria cactivora, Botryosphaeria dothidea, and Fusarium pseudograminearum at a concentration of 100 μg/mL.
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