Older literature on infantile autism accompanied by mental retardation, focussed on epilepsy, cerebral palsy and microcephaly. Multiple adversity was needed to delay growth sufficiently to pruning of connection between Hippocampus and Singulum in its centre, SMA and inhibitory cells in Cerebellum in the synaptogenesis in infancy. Temporary macrocephaly was observed. Today, macrocephaly dominates the discussion. One single adversity, deficient "brain food", seemingly retards growth sufficiently to cause excess pruning with absent activity in inhibitory Purkinje cells in Cerebellum, the SMA and A DEFICIENT, LACKING DELAYED RESPONSE FUNCTION. The brain needs time to adapt, but the Delayed Response Task is lost. Microcephaly predominates at puberty. We wanted to understand cerebellar reactions more fully.
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http://dx.doi.org/10.1177/0260106012437547 | DOI Listing |
J Neuropathol Exp Neurol
January 2025
Neurotraumatology and Subarachnoid Hemorrhage Research Unit, Area 8: Neurosciences and Mental Health, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), Madrid, Spain.
Chitinase 3-like protein 1 (CHI3L1) is emerging as a promising biomarker for assessing intracranial lesion burden and predicting prognosis in traumatic brain injury (TBI) patients. Following experimental TBI, Chi3l1 transcripts were detected in reactive astrocytes located within the pericontusional cortex. However, the cellular sources of CHI3L1 in response to hemorrhagic contusions in human brain remain unidentified.
View Article and Find Full Text PDFBr J Hosp Med (Lond)
December 2024
Department of Rheumatology, University College London (UCL) Hospital Foundation Trust, London, UK.
Sjögren disease (SjD) is a systemic autoimmune disorder affecting both children and adults, with a wide range of clinical phenotypes. It remains a challenging condition to recognise and diagnose early and manage effectively. The heterogeneous nature of the presentation, variable disease course and overlapping symptoms with other autoimmune conditions often result in delayed diagnosis.
View Article and Find Full Text PDFFront Psychol
January 2025
Dornsife Center for Self-Report Science and Center for Economic and Social Research, University of Southern California, Los Angeles, CA, United States.
Introduction: Delayed responses are a common yet often overlooked aspect of participant compliance in ecological momentary assessment (EMA) research. This study investigated whether response delays introduce selection bias in the moments captured by EMA.
Methods: Participants ( = 339) self-reported their physical activity behaviors using EMA five times a day over 7 days while wearing a continuous physical activity monitor.
Transl Lung Cancer Res
December 2024
Department of Cancer Center, Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Background: Health-related quality of life (HRQoL) is critical for patients with lung cancer due to poor prognosis. We presented patient-reported outcomes in patients with non-small cell lung cancer (NSCLC) brain metastases (BM) who received whole-brain radiotherapy (WBRT) in combination with erlotinib or WBRT alone in the phase 3 ENTER study.
Methods: The patients' HRQoL was assessed by using the European Organization for Research and Treatment of Cancer 30-item Core Quality of Life Questionnaire (EORTC QLQ-C30).
Cureus
December 2024
Ear Nose and Throat, Bahrain Defense Force Hospital, Royal Medical Services, Manama, BHR.
Objective: The aim of this study was to assess hearing level of preschoolers with delayed speech in order to detect any underlying hearing loss Methods: In this research we targeted preschool children with speech delay, who have not been previously diagnosed with any medical or psychological illnesses. A total of 54 preschool speech-delayed children were audiologically assessed in our clinic in the past year. The age at time of referral ranged from two to 7.
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