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The Dual Role of Survival Genes in Neurons and Cancer Cells: a Strategic Clinical Application of DX2 in Neurodegenerative Diseases and Cancer.
Biomol Ther (Seoul)
January 2025
Department of Pharmacology, College of Dentistry and Research Institute of Oral Science, Gangneung-Wonju National University, Gangneung 25457, Republic of Korea.
In cancer cells, survival genes contribute to uncontrolled growth and the survival of malignant cells, leading to tumor progression. Neurons are post-mitotic cells, fully differentiated and non-dividing after neurogenesis and survival genes are essential for cellular longevity and proper functioning of the nervous system. This review explores recent research findings regarding the role of survival genes, particularly DX2, in degenerative neuronal tissue cells and cancer cells.
View Article and Find Full Text PDFDual inhibition of aminoacyl-tRNA synthetase interacting multifunctional protein-2 and α-synuclein by steroid derivative is neuroprotective in Parkinson's model.
iScience
November 2024
Department of Pharmacology, Sungkyunkwan University School of Medicine, Samsung Biomedical Research Institute, Suwon 16419, Republic of Korea.
Aminoacyl-tRNA synthetase interacting multifunctional protein-2 (AIMP2), a parkin substrate, possesses self-aggregating properties, potentiating α-synuclein aggregation and neurotoxicity in PD. Thus, targeting both α-synuclein and AIMP2 would present an effective treatment for PD pathologies. Herein, we developed small compounds with dual inhibitory activity against AIMP2 and α-synuclein.
View Article and Find Full Text PDFAIMP1-Derived Peptide Secreted from Hair Follicle Stem Cells Promotes Hair Growth by Activating Dermal Papilla Cells.
Int J Biol Sci
November 2024
Department of Integrative Biotechnology, Interdisciplinary Graduate Program, College of Pharmacy, Medicinal Bioconver-gence Research Center, Institute for Artificial Intelligence and Biomedical Research, Gangnam Severance Hospital, Yonsei University, 85 Songdogwahak-ro, Yeonsu-gu, Incheon 21983, South Korea.
Hair follicle stem cells (HFSCs) and dermal papilla cells (DPCs) are crucial in the biogenesis and maintenance of hair follicles (HFs). This study demonstrated that a fragment derived from aminoacyl-tRNA synthetase-interacting multifunctional protein1 (AIMP1) secreted from HFSCs activated DPCs and maintained HF homeostasis. A histological analysis revealed that AIMP1 levels in HF decreased with hair loss.
View Article and Find Full Text PDFAIMP2 accumulation in brain leads to cognitive deficits and blood secretion in Parkinson's disease.
J Transl Med
October 2024
Department of Pharmacology, Sungkyunkwan University School of Medicine, Suwon, 16419, Republic of Korea.
Article Synopsis
- Accumulation of the protein AIMP2 in the brain is linked to cognitive decline in Parkinson's disease (PD), specifically in areas like the temporal lobe and hippocampus.
- Research involved imaging and experiments with transgenic mice to evaluate how AIMP2 affects neuron health and cognitive function, revealing its toxicity to hippocampal neurons.
- The study also suggested that AIMP2 could serve as a potential biomarker for PD, as higher levels of this protein were found in the plasma of patients compared to healthy controls.
Anti-aminoacyl-tRNA synthetase-interacting multifunctional protein-1 antibody improves airway inflammation in mice with house dust mite induced asthma.
World Allergy Organ J
September 2024
Institute of Allergy, Yonsei University College of Medicine, Seoul, Republic of Korea.
Background: Several biologics have been developed and used to treat severe asthma. However, commercialized biologics have limitations in treating T2-low asthma because their main target is the T2 inflammation marker. Therefore, there is an unmet need for treating T2-low severe asthma.
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