Inflammation has recently been implicated as a critical mechanism responsible for neurodegenerative diseases. In this study, paeonol (1-(2-hydroxy-4-methoxyphenyl)ethanone) isolated from the sea horse Hippocampus kuda Bleeler was studied as an agent to suppress LPS induced activation of BV-2 microglial and RAW264.7 macrophage cells. The results obtained showed that paeonol significantly suppressed LPS induced release of pro-inflammatory products such as nitric oxide (NO), prostaglandin E2 (PGE(2)), and cytokines; tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and interleukin-6 (IL-6). Furthermore, the compound down regulated the protein and gene expression levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), TNF-α, IL-1β and IL-6 in both cell lines. Molecular signaling pathway studies showed that paeonol inhibited the translocation of nuclear factor-κB (NF-κB) p65 and p50 subunits to the nucleus by blocking IKKα/β (IκB kinase α/β) mediated degradation of IκBα. Moreover, it suppressed the phosphorylation of mitogen activated protein kinase (MAPK) pathway molecules; c-Jun N-terminal kinases (JNK) and p38 in both cell lines. Collectively these results indicate that paeonol blocked the LPS stimulated inflammatory responses in BV-2 and RAW264.7 cells via modulating MAPK and NF-κB signaling pathways. Therefore, paeonol could be a promising candidate to be used in neuro-inflammatory therapy.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.tiv.2012.04.022 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The common seahorse, Hippocampus kuda, is widely distributed throughout the Indo-Pacific region, occurring from East Africa to Hawaii, where it typically inhabits diverse ecosystems such as estuaries, lagoons, coastal zones, and seagrass beds. Despite its extensive geographic range, reports of its occurrence in the Red Sea remains limited, primarily restricted to the northern region of the Red Sea. Here, we report a new distributional record of H.
View Article and Find Full Text PDFAdaptability and growth of and under rapid temperature changes.
Front Physiol
September 2024
Key Laboratory of Aquacultural Biotechnology of MOE, School of Marine Science, Ningbo University, Ningbo, China.
Article Synopsis
- Temperature changes affect how fish grow in fish farms, based on how much the temperature changes and how fast it changes.
- Researchers looked at two types of fish that can adjust to different temperatures and checked how they reacted to slower and faster temperature changes.
- The study found that some fish grew well even when temperatures changed slowly, but faster changes made a big difference in how they fed and grew, showing some fish are more sensitive to temperature changes than others.
The United States dried seahorse trade: A comparison of traditional Chinese medicine and ecommerce-curio markets using molecular identification.
PLoS One
October 2023
Subprogram in Ecology, Evolution Biology and Behavior, The Graduate Center of the City University of New York, New York, New York, United States of America.
Tens of millions of dried seahorses (genus Hippocampus) are traded annually, and the pressure from this trade along with their life history traits (involved parental care and small migration distances and home ranges) has led to near global population declines. This and other forms of overexploitation have led to all seahorse species being listed in Appendix II under the Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES). The signatory nations of CITES recommended a 10-cm size limit of seahorses to ensure harvested individuals have reached reproductive maturity, and have thus had the chance to produce offspring, to maintain a more sustainable global seahorse fishery.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates the combined effects of alcohol extracts from *Hippocampus kuda* and ginseng on enhancing male sexual function by increasing testosterone levels and semen quality.
- The researchers mixed these extracts in a 1:1 ratio, and the results showed a significant improvement in both testosterone levels and semen quality compared to using either extract alone.
- The findings suggest that a daily dosage of 240 mg of the extract mixture per 100 g body weight can effectively boost testosterone, sperm density, and sperm health in rats.
Sperm transport and male pregnancy in seahorses: An unusual model for reproductive science.
Anim Reprod Sci
November 2022
University Institute of Sustainable Aquaculture and Marine Ecosystems (IU ECOAQUA) Scientific and Technological Marine Park, University of Las Palmas de Gran Canaria, 35200, Spain.
The Syngnathidae (seahorses and pipefishes) are a group of teleost fishes in which, uniquely, developing embryos are hosted throughout pregnancy by males, using a specialized brood pouch situated on the abdomen or tail. Seahorses have evolved the most advanced form of brood pouch, whereby zygotes and embryos are intimately connected to the host's circulatory system and also bathed in pouch fluid. The pouch is closed to the external environment and has to perform functions such as gaseous exchange, removal of waste and maintenance of appropriate osmotic conditions, much like the mammalian placenta.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!