AI Article Synopsis
- Trastuzumab combined with chemotherapy is the recommended treatment for HER2 positive breast cancer, but there is limited research on its effects in elderly patients.
- A systematic review indicated a significant 47% reduction in risk for those over 60 receiving trastuzumab compared to chemotherapy alone, while cardiac events were relatively low at 5%.
- Despite the effectiveness of trastuzumab in this age group, it's important to assess individual health factors and address ongoing concerns about cardiac safety during treatment.
Article Abstract
Trastuzumab, in combination with chemotherapy, is the gold standard in the adjuvant treatment of patients with HER2 positive breast cancer. Limited data are available on the role of adjuvant trastuzumab in the elderly population. We performed a systematic review of prospective randomized trials with available data on the use of adjuvant trastuzumab in patients older than 60years, focusing on both the efficacy and the cardiac safety. Data extrapolated from two prospective trials were included for efficacy and cardiac safety. A significant 47% relative risk reduction was observed in elderly patients receiving trastuzumab compared to chemotherapy alone (pooled Hazard Ratio: 0.53; 95% CI, 0.36-0.77). The pooled proportion of cardiac events in elderly patients treated with trastuzumab was 5% (95% CI, 4-7%). The use of trastuzumab should be considered as a standard of care in the adjuvant therapy of elderly patients with HER-2 positive breast cancer. Acute and chronic medical conditions, nutritional status and level of daily activities should be considered. Uncertainty about cardiac safety in the elderly is a major concern.
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| http://dx.doi.org/10.1016/j.ctrv.2012.03.009 | DOI Listing |
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