Background: The nature of microembolic signals (MES) in patients without apparent sources of embolism remains elusive. We hypothesize that MES in acute stroke patients without an embolic source may represent a transient phenomenon related to blood rheology or clot dissolving, in which case the characteristics of such MES would differ from those with definitive sources of emboli.
Methods: We compared the intensity and duration of 250 MES in 62 acute nonembolic stroke patients (stroke group) and 217 MES in 57 patients with asymptomatic carotid stenosis (≥50%; carotid group).
Results: The duration of MES was significantly different between the 2 groups (24.86 ± 0.89 ms in the carotid group v 18.8 ± 0.83 in the stroke group; P < .001). When comparing the groups for MES with an intensity higher than 6 dB, a highly significant difference in the duration of MES was found (27.87 ± 1.26 ms in the carotid group v 18.57 ± 1.29 ms in the stroke group; P < .0001). A strong linear relationship between the duration and intensity of MES was found for the carotid group, but not for the stroke group.
Conclusions: There are significant differences between the characteristics of MES in acute stroke patients as compared with MES in patients with carotid plaques. There is a strong correlation between the intensity and duration of MES from a definitive embolic source, which is absent from MES in patients with nonembolic stroke. These findings may point to the different mechanisms of MES origin in the examined groups.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jstrokecerebrovasdis.2012.03.017 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Occurrence and associated factors of self-reported medical errors among Chinese physicians and nurses: a cross-sectional survey.
Ann Med
December 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Background: Medical errors (MEs) significantly threaten patient safety globally. This study aimed to explore multidimensional factors associated with self-reported MEs among Chinese physicians and nurses.
Methods: A cross-sectional online survey using snowball sampling collected 7197 valid responses from Chinese physicians and nurses between October 2020 and April 2022.
Single-cell multi-omics analysis reveals candidate therapeutic drugs and key transcription factor specifically for the mesenchymal subtype of glioblastoma.
Cell Biosci
December 2024
Clinical Pharmacy Center, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, Guangdong, China.
The inherent heterogeneity of tumor cells impedes the development of targeted therapies for specific glioblastoma (GBM) subtypes. This study aims to investigate the mesenchymal subtype of GBM to uncover detailed characteristics, potential therapeutic strategies, and improve precision treatment for GBM patients. We integrated single-cell RNA sequencing (scRNA-seq), single-nucleus assay for transposase-accessible chromatin sequencing (snATAC-seq), and bulk RNA sequencing datasets to identify core gene modules, candidate therapeutic drugs, and key transcription factors specific to mesenchymal subtype GBM tumor cells which we validated in vitro and human samples.
View Article and Find Full Text PDFMicroembolic signal detection in acute ischemic stroke: Clinical relevance and impact on treatment individualization-A narrative review.
Eur J Neurol
January 2025
Second Department of Neurology, School of Medicine, "Attikon" University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Background: Microembolic signals (MES) can be detected using transcranial Doppler (TCD) ultrasound in several clinical scenarios, including acute ischemic stroke (AIS). This narrative review aims to provide insights into their role in AIS patient management and outcomes.
Methods: The present narrative review consolidates current observational and randomized evidence on the prevalence and clinical relevance of MES in different AIS subtypes and settings.
Results at one year of the TROPIS technique in the treatment of complex anal fistula.
Cir Esp (Engl Ed)
December 2024
Full professor at the University of Seville, Department of General and Digestive Surgery, Head of the Coloproctology Unit, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Introduction: It is a priority to find surgical techniques that guarantee acceptable healing rates without sequelae in the treatment of complex anal fistula. The concept of the deep intersphincteric space as the origin of perianal sepsis has provided a new perspective, allowing the emergence of techniques such as TROPIS (Transanal Opening of Intersphincteric Space), with few published series to date. The aim of this study is to evaluate the healing rate and complications one year after the TROPIS technique as a treatment for complex anal fistula without hospitalization.
View Article and Find Full Text PDFHistological, But Neither Clinical Nor Endoscopic Activity Predicts the Risk of Colectomy in Patients With Ulcerative Colitis Treated With Biologics.
Inflamm Bowel Dis
December 2024
Gastro Unit - Medical Section, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.
Background: Biological treatment failure is common in patients with ulcerative colitis (UC), but the predictive value of baseline histological activity is unknown.
Aims: We aimed to investigate the associations between baseline histological activity and outcomes after biological treatment in patients with UC.
Methods: Adult biological-naïve patients with UC (n = 150) were followed prospectively during biological treatment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!