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Anti-GluK2 Encephalitis in an Asian Child: A Case Report and Literature Review.
Immunotargets Ther
December 2024
Department of Pediatrics, Xiangya Hospital, Central South University, Changsha, People's Republic of China.
Background: Anti-glutamate kainate receptor subunit 2 (anti-GluK2) antibodies mediated encephalitis is very rare in both children and adults. This study aimed to describe the second report of the anti-GluK2 encephalitis worldwide, the first youngest patient worldwide, and the first case ever in Asia. Besides, this study provides a summary of the clinical manifestations of all previous reported cases.
View Article and Find Full Text PDFLate relapse of anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis: a case report.
J Med Case Rep
November 2024
Department of Pediatrics, Arak University of Medical Sciences, Arak, Iran.
Article Synopsis
- Anti-N-methyl-D-aspartate receptor encephalitis is a serious autoimmune brain disorder mainly affecting young females, causing various neuropsychiatric symptoms like seizures and psychosis.
- A 16-year-old Iranian girl experienced a rare relapse of this condition 8 years after her initial diagnosis, presenting with speech and reading difficulties, confirmed by specific antibodies in her body fluids.
- She fully recovered after treatment with immunotherapy and plasmapheresis, highlighting the need for long-term monitoring of patients due to the possibility of late relapses.
Design, green synthesis, and anti-glutamate damage screening of chalcone derivatives with spiro-heterocyclic structures as potential anti-ischemic brain and eye damage agents.
Bioorg Chem
December 2024
The Eye Hospital, School of Ophthalmology & Optometry, Wenzhou Medical University, Wenzhou 325027, China; The 1st Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China. Electronic address:
Article Synopsis
- - Researchers focused on reducing excessive glutamate toxicity to treat brain and retinal damage in ischemic stroke patients, developing new 3-benzoyl-4-phenyl-spiropyrrolidone compounds.
- - They screened these compounds for protective effects on PC12 cells and established a structure-activity relationship (QSAR) model with a strong correlation (R = 0.90723).
- - The best compound, E38, showed significant protective effects in cell cultures and in a mouse model, reducing brain damage and improving neurological function, indicating its potential as a treatment for ischemic stroke.
Autoimmune Encephalitis in a Patient with a Solitary Intracranial Plasmacytoma.
Intern Med
November 2024
Department of Neurology and Neuroscience, Nagoya City University Graduate School of Medical Sciences, Japan.
A 65-year-old woman presented with fever and abnormal behavior. Magnetic resonance imaging showed swelling of the left medial temporal lobe and an intracranial extra-axial occipital tumor. While her neurological symptoms improved after the administration of corticosteroid therapy under the suspicion of autoimmune encephalitis, the occipital tumor unexpectedly shrank, and the diagnosis of a solitary plasmacytoma was confirmed by biopsy.
View Article and Find Full Text PDFMultiple serum anti-glutamate receptor antibody levels in clozapine-treated/naïve patients with treatment-resistant schizophrenia.
BMC Psychiatry
April 2024
Department of Psychiatry, Sir Run-Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Background: Glutamatergic function abnormalities have been implicated in the etiology of treatment-resistant schizophrenia (TRS), and the efficacy of clozapine may be attributed to its impact on the glutamate system. Recently, evidence has emerged suggesting the involvement of immune processes and increased prevalence of antineuronal antibodies in TRS. This current study aimed to investigate the levels of multiple anti-glutamate receptor antibodies in TRS and explore the effects of clozapine on these antibody levels.
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