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m6A methylation profiling as a prognostic marker in nasopharyngeal carcinoma: insights from MeRIP-Seq and RNA-Seq.
Front Immunol
December 2024
Department of Radiation Oncology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, China.
Background: Nasopharyngeal carcinoma (NPC) is a type of malignant tumors commonly found in Southeast Asia and China, with insidious onset and clinical symptoms. N6-methyladenosine (m6A) modification significantly contributes to tumorigenesis and progression by altering RNA secondary structure and influencing RNA-protein binding at the transcriptome level. However, the mechanism and role of abnormal m6A modification in nasopharyngeal carcinoma remain unclear.
View Article and Find Full Text PDFSingle-cell RNA sequencing reveals the critical role of alternative splicing in cattle testicular spermatagonia.
Biol Direct
December 2024
Key Laboratory of Livestock and Poultry Multi-omics of MARA, Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences, Jinan, 250100, P. R. China.
Spermatogonial stem cells (SSCs) form haploid gametes through the precisely regulated process of spermatogenesis. Within the testis, SSCs undergo self-renewal through mitosis, differentiation, and then enter meiosis to generate mature spermatids. This study utilized single-cell RNA sequencing on 26,888 testicular cells obtained from five Holstein bull testes, revealing the presence of five distinct germ cell types and eight somatic cell types in cattle testes.
View Article and Find Full Text PDFHow Physical Exercise Reduces Problematic Mobile Phone Use in Adolescents: The Roles of Expression Suppression, Depression, Anxiety, and Resilience.
Psychol Res Behav Manag
December 2024
Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, People's Republic of China.
Background: Problematic mobile phone use has become a pressing concern among adolescents due to its widespread prevalence and associated health risks. Physical exercise has been suggested as a potential intervention, but the psychological mechanisms underlying its effects remain unclear. This study explores how physical exercise impacts problematic mobile phone use through expression suppression, emotional problems (depression and anxiety), and resilience, offering actionable insights for intervention strategies.
View Article and Find Full Text PDFFrom mere 'stability' to 'durability'-Revisiting intention dynamics from a self-regulatory perspective with intensive longitudinal methods.
Appl Psychol Health Well Being
February 2025
University of Bremen, Bremen, Germany.
Behavioral intentions predict behavior better if they are stable over time. A statistical argument suggests that this is due to less measurement error, but recent theoretical advances suggest self-regulatory effects: durable intentions remain temporally stable due to their persistence when faced with challenges. Here, we leverage intensive longitudinal data on adherence with non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic (N = 623; total assessments = 19,740; study duration: 6 months each).
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