The calculation of transport profiles from experimental measurements belongs in the category of inverse problems which are known to come with issues of ill-conditioning or singularity. A reformulation of the calculation, the matricial approach, is proposed for periodically modulated experiments, within the context of the standard advection-diffusion model where these issues are related to the vanishing of the determinant of a 2×2 matrix. This sheds light on the accuracy of calculations with transport codes, and provides a path for a more precise assessment of the profiles and of the related uncertainty.
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http://dx.doi.org/10.1103/PhysRevLett.108.125007 | DOI Listing |
The marginal wells in low-permeability oil fields are characterized by small storage size, scattered distribution, intermittent production, etc. The construction of large-scale gathering pipelines has large investment. So the current production mode is featured by single well tank oil storage, oil tank truck transportation and manual tank truck scheduling.
View Article and Find Full Text PDFProteins
January 2025
Institute of Transformative bio-Molecules, Nagoya University, Nagoya, Japan.
In plants, sugar will eventually be exported transporters (SWEETs) facilitate the translocation of mono- and disaccharides across membranes and play a critical role in modulating responses to gibberellin (GA3), a key growth hormone. However, the dynamic mechanisms underlying sucrose and GA3 binding and transport remain elusive. Here, we employed microsecond-scale molecular dynamics (MD) simulations to investigate the influence of sucrose and GA3 binding on SWEET13 transporter motions.
View Article and Find Full Text PDFGenome Med
January 2025
Otology & Neurotology Group CTS495, Instituto de Investigación Biosanitario, Ibs.GRANADA, Universidad de Granada, 18071, Granada, Spain.
Background: Familial Meniere's disease (FMD) is a rare polygenic disorder of the inner ear. Mutations in the connexin gene family, which encodes gap junction proteins, can also cause hearing loss, but their role in FMD is largely unknown.
Methods: We retrieved exome sequencing data from 94 individuals in 70 Meniere's disease (MD) families.
Sci Rep
January 2025
College of Transportation Science and Engineering, Nanjing Tech University, Nanjing, 211816, China.
Large-scale rock burst disasters often occur in high-stress and deep-buried tunnels, due to challenges in accurate forecasting and the lack of clarity regarding the underlying mechanisms largely. This study combined on-site stress drilling tests, coupled finite and discrete element simulations, and theoretical calculations to examine unloading damage, rockburst evolution, and deformation failure of the high-stress and deep-buried Xuefengshan No.1 tunnel.
View Article and Find Full Text PDFJMIR Cancer
January 2025
Department of Health and Kinesiology, University of Utah, Salt Lake City, UT, United States.
Background: Exercise can attenuate the deleterious combined effects of cancer treatment and aging among older adults with cancer, yet exercise participation is low. Telehealth exercise may improve exercise engagement by decreasing time and transportation barriers; however, the utility of telehealth exercise among older adults with cancer is not well established.
Objective: We aimed to evaluate the preliminary effectiveness of a one-on-one, supervised telehealth exercise program on physical function, muscular endurance, balance, and flexibility among older adults with cancer.
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