AI Article Synopsis
- Phosphorus is crucial for many biological functions, making its regulation and balance essential for an organism's health.
- Recent research has identified a phosphate-sensing system in various organs and new intestinal factors that influence how the kidneys excrete phosphate after eating meals high in phosphate.
- Studies indicate that the NaPi-IIb cotransporter in the small intestine plays a key role in absorbing phosphate, potentially linking dietary phosphate intake to kidney function to keep phosphate levels stable.
Article Abstract
Since phosphorus plays a critical role in diverse biological processes, regulation of the phosphorus balance and homeostasis are critical to the well-being of the organism. Recent findings point to the presence of a phosphate-sensing mechanism in the various organs and the presence of novel intestinal effectors that alter the renal phosphate excretion after the ingestion of a phosphate-containing meal. Recent studies have provided strong evidence that the sodium-phosphate cotransporter NaPi-IIb is responsible for sodium-dependent phosphate absorption by the small intestine, and this protein might link changes in dietary phosphate to altered renal phosphate excretion in order to maintain the phosphate balance. It has been established that different regions of the small intestine respond differently to acute or chronic changes in dietary phosphate load and that phosphatonins inhibit both renal and intestinal phosphate transport.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!