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Combined Input Deep Learning Pipeline for Embryo Selection for In Vitro Fertilization Using Light Microscopic Images and Additional Features.
J Imaging
January 2025
Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok 10330, Thailand.
The current process of embryo selection in in vitro fertilization is based on morphological criteria; embryos are manually evaluated by embryologists under subjective assessment. In this study, a deep learning-based pipeline was developed to classify the viability of embryos using combined inputs, including microscopic images of embryos and additional features, such as patient age and developed pseudo-features, including a continuous interpretation of Istanbul grading scores by predicting the embryo stage, inner cell mass, and trophectoderm. For viability prediction, convolution-based transferred learning models were employed, multiple pretrained models were compared, and image preprocessing techniques and hyperparameter optimization via Optuna were utilized.
View Article and Find Full Text PDFImproving fertilization rates in IVF using rutin and quercetin in preculture medium or through oral administration.
Front Vet Sci
January 2025
Faculty of Pharmaceutical Sciences, Nagasaki International University, Sasebo, Nagasaki, Japan.
Fertility rates are declining in livestock such as cattle, and more than one in five Japanese couples have undergone infertility treatment or are currently infertile. Improving the fertilization rates of domesticated animals is imperative for improving their productivity and maintaining valuable lineages. In this study, the effects of rutin and quercetin on fertility and pregnancy rates were investigated by incorporating these compounds into the preculture medium for fertilization (IVF) or administering them orally to mice.
View Article and Find Full Text PDFComparing gestational carrier to uterine transplantation in uterine-factor infertility: a cost-effectiveness analysis.
Fertil Steril
January 2025
Shady Grove Fertility, Rockville, MD, USA.
Objective: To compare the cost-effectiveness of a gestational carrier to a uterine transplantation in the treatment of absolute uterine-factor infertility.
Design: We performed a cost-effectiveness analysis using a decision-tree mathematical model comparing a gestational carrier to a uterine transplantation.
Subjects: Published literature was used to derive costs for solid organ transplant, immunosuppression, gestational carrier obtainment, in vitro fertilization, preimplantation genetic testing, and frozen embryo transfer.
Infection Prevention observations and the expectations of cleaning practices in an Assisted Reproductive Technology (ART)/In-Vitro Fertilization (IVF) Clinic: The Challenges.
Am J Infect Control
January 2025
Department of Infection Prevention, Barnes-Jewish Hospital, St. Louis MO.
Infection Prevention (IP) observations in clinic and procedure areas is a growing area of interest and concern. IP guidance for observations in an IVF clinic are challenging. This is related to care of the mom and the embryo.
View Article and Find Full Text PDFAssociation of anti-phosphatidylserine/prothrombin antibodies with adverse in vitro fertilization outcomes.
J Reprod Immunol
January 2025
Reproductive and Genetic Center, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China. Electronic address:
Anti-phosphatidylserine/prothrombin antibodies (aPS/PT) are classified as non-criteria antiphospholipid antibodies (aPL), and are strongly associated with thrombosis and pregnancy complications linked to antiphospholipid syndrome (APS). This study aimed to investigate whether aPS/PT positivity is associated with adverse outcomes in vitro fertilization (IVF). The study included infertile women who tested positive aPS/PT and underwent IVF cycles, as well as infertile controls with pure tubal etiology.
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