AI Article Synopsis
- Celiac disease (CD) is an autoimmune disorder triggered by gluten, leading to damage in the small intestine and associated with reproductive issues and pregnancy complications.
- A study in Italy aimed to identify undiagnosed CD in mothers of small for gestational age (SGA) newborns compared to those with appropriate for gestational age (AGA) newborns, involving 480 mothers.
- The researchers found two new cases of CD in asymptomatic mothers, suggesting that testing for tissue transglutaminase type 2 antibodies (TG2) should be included in prenatal blood tests.
Article Abstract
Celiac disease (CD), an autoimmune disease triggered by dietary gluten, is a multi-systemic disorder that primarily results in mucosal damage of the small intestine. Reproductive disorders and pregnancy complications have been associated with CD. Conflicting results have been published concerning CD and the risk of impaired fetal growth with reduced birthweight. The aim of our multicentric, perspective, case-control study was to determine the prevalence of undiagnosed CD in mothers of small for gestational age (SGA) newborns in two regions of Italy. The study included 480 mothers: group A consisted of 284 SGA newborns' mothers and group B consisted of 196 appropriate for gestational age (AGA) newborns' mothers. Tissue transglutaminase type 2 antibodies (TG2) IgA and IgG were measured in blood samples. We diagnosed two new cases of CD in asymptomatic mothers. It may be appropriate to include the TG2 to the panel of prenatal blood test.
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| http://dx.doi.org/10.3109/08923973.2012.680470 | DOI Listing |
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