Laboratory of Mammalian Molecular Biology, Graduate School of Biostudies, Kyoto University Kyoto, Japan.
Published: October 2012
AI Article Synopsis
Article Abstract
Human papillomaviruses (HPVs) target the stratified epidermis, and can causes diseases ranging from benign condylomas to malignant tumors. Infections of HPVs in the genital tract are among the most common sexually transmitted diseases, and a major risk factor for cervical cancer. The virus targets epithelial cells in the basal layer of the epithelium, while progeny virions egress from terminally differentiated cells in the cornified layer, the surface layer of the epithelium. In infected basal cells, the virus maintains its genomic DNA at low-copy numbers, at which the viral productive lifecycle cannot proceed. Progression of the productive lifecycle requires differentiation of the host cell, indicating that there is tight crosstalk between viral replication and host differentiation programs. In this review, we discuss the regulation of the HPV lifecycle controlled by the differentiation program of the host cells.
Soil conditions of croplands are a frequent topic of scientific research. In contrast, less is known about large-scale commercial plantations of perennial crops such as oil palm. Oil palm is a globally important tropical commodity crop which contributes to both food and energy security due to its exceptional productivity.
This study evaluated an innovative strategy for valorizing grape stems (GS) from the winery industry as an animal feed ingredient from both environmental life-cycle and economic perspectives. Two processes for GS-based feed ingredient production were compared: one using hydrolyzed GS and the other using nonhydrolyzed GS, alongside the conventional animal feed production process. Using primary pilot-scale data for GS-based feed ingredient production and secondary data for animal feed production, life-cycle assessments, and economic analyses were conducted.
University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK; National Institute for Health and Care Research (NIHR) Birmingham Biomedical Research Centre, Birmingham, UK; Centre for Patient Reported Outcomes Research, School of Health Sciences, College of Medical and Dental Sciences, Birmingham, UK; University of Birmingham, Birmingham, UK. Electronic address:
Without careful dissection of the ways in which biases can be encoded into artificial intelligence (AI) health technologies, there is a risk of perpetuating existing health inequalities at scale. One major source of bias is the data that underpins such technologies. The STANDING Together recommendations aim to encourage transparency regarding limitations of health datasets and proactive evaluation of their effect across population groups.
The peptidoglycan manifests as a multifaceted component of the bacterial cell wall. Throughout the lifecycle of the bacterium, the peptidoglycan is deconstructed, rebuilt, and remodeled for bacterial cell growth and replication. Degradation products of the peptidoglycan serve as precursors for cell-wall building blocks via recycling processes and as signaling molecules.
Wageningen University & Research, Animal Production Systems Group, 6706 WD Wageningen, the Netherlands; Christian Albrechts University, Grass and Forage Science/Organic Agriculture, D-24118 Kiel, Germany.
The integration between crop and livestock production systems (ICLS) at regional level is seen as a pathway for more sustainable food production. The objective was to assess the effects on farm structure, economic performance and environmental impact of an ICLS with varying constraints on agricultural emissions, changes in land use and a lower external input use as means to achieve environmental targets. A linear optimization model was used for economic optimization of ICLS under different scenarios for the case of crop and dairy production systems on sandy soils in the Netherlands.
