AI Article Synopsis
- The study examines the long-term effects of aliskiren, a medication, on blood pressure in hypertensive patients undergoing hemodialysis.
- Among 25 patients, those who continued with aliskiren treatment saw significant reductions in blood pressure and levels of key hormones linked to blood pressure regulation over a 20-month period.
- The findings suggest that long-term use of aliskiren is effective in lowering blood pressure and inhibiting the renin-angiotensin-aldosterone system in these patients.
Article Abstract
Objective: The long-term effects of aliskiren in hypertensive hemodialysis patients remain to be elucidated.
Design: In this post hoc analysis, we followed up 25 hypertensive hemodialysis patients who completed 8-week aliskiren treatment in a previous study for 20 months to investigate the blood pressure-lowering effect and inhibitory effect on the renin-angiotensin-aldosterone system.
Results: Among the 25 patients, eleven patients continued with aliskiren treatment. Blood pressure (± standard deviation) decreased from 175 ± 18/80 ± 11 mmHg at baseline to 156 ± 20/76 ± 9 mmHg at month 20. Plasma renin activity, angiotensin I, and angiotensin II decreased from baseline to month 20 (plasma renin activity (ng/mL/h): 2.3 ± 2.6 to 0.3 ± 0.4 (P < 0.05), angiotensin I (pg/mL): 909.1 ± 902.5 to 41.5 ± 14.8 (P < 0.05), angiotensin II (pg/mL): 41.5 ± 45.8 to 11.0 ± 4.9 (P < 0.05)).
Conclusion: Long-term treatment with aliskiren provides effective blood pressure lowering and inhibition of the renin-angiotensin-aldosterone system, which are sustained over 20 months in hypertensive hemodialysis patients.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3333807 | PMC |
| http://dx.doi.org/10.2147/IJNRD.S30203 | DOI Listing |
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