AI Article Synopsis
- Hypertension is linked to inflammation and is often seen with obesity, impacting the body's acute-phase response.
- A study involving 92 hypertensive patients and 75 healthy controls found higher levels of hsCRP and AGP in hypertensives, particularly among smokers.
- The findings suggest that hypertension triggers acute-phase responses, with specific markers elevated in smokers and certain markers like serum C3 complement increased in those who are both hypertensive and obese.
Article Abstract
Background: Hypertension is a powerful risk factor for cardiovascular disease and frequently occurs in conjunction with obesity. Accumulative evidence suggests a link between inflammation and hypertension. The aim of study was to evaluate whether blood pressure, obesity and smoking may influence acute-phase response.
Material/methods: Ninety-two patients with essential hypertension and 75 healthy volunteers as a control group were studied. In all subjects assessment of hsCRP, alpha1-acid glycoprotein (AGP), alpha1-antichymotrypsin, transferrin, alpha1-antitrypsin, and C3 and C4 complement were performed. Evaluation of glycosylation profile and reactivity coefficient (RC) for AGP was done by means of affinity immunoelectrophoresis with concanavalin A as a ligand.
Results: When compared to the controls, hypertensive subjects presented significantly higher hsCRP concentrations and lower transferrin level. Hypertensive patients had elevated AGP-AC. The intensification of the inflammatory reaction was greater in the subgroup of hypertensive patients smoking cigarettes. In obese hypertensives, elevated serum C3 complement level was found.
Conclusions: We conclude that arterial hypertension may evoke the acute-phase response in humans. Markers of acute-phase response are particularly strongly expressed in smokers. Serum C 3 complement, but not other APPs, is elevated in hypertension coexisting with obesity.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560623 | PMC |
| http://dx.doi.org/10.12659/msm.882740 | DOI Listing |
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