AI Article Synopsis
- - A study evaluated the effectiveness of 13 antibiotics against 85 Brucella abortus samples from cattle in South Korea between 1998 and 2006 using a broth microdilution test.
- - Tetracyclines were found to be the most effective, with minocycline showing the lowest MIC values of 0.125 μg/ml.
- - Ciprofloxacin was the most effective among fluoroquinolones, while gentamicin outperformed other antibiotics like streptomycin and erythromycin in treating B. abortus infections.
Article Abstract
In vitro activities of 13 antibiotics were assessed against 85 Brucella abortus isolates from naturally infected cattle in the Republic of Korea during 1998-2006, using broth microdilution test. Tetracyclines showed the most excellent activity against B. abortus, displaying MIC values of 0.5 μg/ml or below. In particular, minocycline showed the lowest MIC₅₀/₉₀ values (0.125/0.125 μg/ml) in this study. Among four fluoroquinolones tested, ciprofloxacin (MIC₅₀/₉₀, 0.5/1 μg/ml) and norfloxacin (MIC₅₀/₉₀, 8/8 μg/ml) had the most and the least activities, respectively. Gentamicin (MIC₅₀/₉₀, 1/1 μg/ml) was more effective than streptomycin, erythromycin, rifampin, and chloramphenicol (MIC₅₀/₉₀, 2/2 μg/ml).
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| http://dx.doi.org/10.4014/jmb.1109.09013 | DOI Listing |
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