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Safety outcome trials in four mainline medical journals 30 years apart: a narrative review and the need for the transparency of informed consents.
Trials
January 2025
Internal Medicine (Rheumatology), Academic Hospital, Istanbul, Turkey.
Background: It was our impression that safety outcome trials were getting more frequent, raising ethical issues mainly related to patient autonomy. We and others had also proposed this autonomy would be best served if wording of the informed consents would be in the public domain.
Methods: Initially two observers and an arbiter tabulated the main aims of randomized controlled trials (RCTs) published in 1990-1991 vs.
The Definition and Diagnostic Criteria for Flexion Instability after Total Knee Arthroplasty is Highly Variable in the Published Literature.
J Arthroplasty
January 2025
Department of Orthopaedic Surgery, University of Virginia, 2280 Ivy Road, Charlottesville, Virginia.
Introduction: Flexion instability (FI) is increasingly being recognized as a common reason for failure after total knee arthroplasty (TKA). However, the diagnosis remains loosely defined and is often described by a constellation of symptoms and findings with the exclusion of other clinical entities. The purpose of this study was to examine the definition and diagnostic criteria of FI used in the current peer-reviewed literature.
View Article and Find Full Text PDFUnderstanding Patterns of the Gut Microbiome May Contribute to the Early Detection and Prevention of Type 2 Diabetes Mellitus: A Systematic Review.
Microorganisms
January 2025
Department Neuromed & Movement Science, Norwegian University of Science & Technology (NTNU), 7034 Trondheim, Norway.
The rising burden of type 2 diabetes mellitus (T2DM) is a growing global public health problem, particularly prominent in developing countries. The early detection of T2DM and prediabetes is vital for reversing the outcome of disease, allowing early intervention. In the past decade, various microbiome-metabolome studies have attempted to address the question of whether there are any common microbial patterns that indicate either prediabetic or diabetic gut microbial signatures.
View Article and Find Full Text PDFD1S-Neuro Program: Frequency and Risk Factors for the Development of Diabetic Neuropathy in Pediatric Patients with Type 1 Diabetes Mellitus, a Single Center Study.
Biomedicines
December 2024
Pediatric Diabetes Unit, Department of Women's and Children's Health, University Hospital of Padua, 35128 Padua, Italy.
Diabetic neuropathy is the most common long-term complication of diabetes mellitus, widely studied in the adult population, but its prevalence in children and adolescents has not yet been clearly defined. Diabetic patients over 11 years old and with at least 5 years of diabetes were subjected to specific tests for the screening of diabetic peripheral neuropathy (DPN) and for the diagnosis of cardiac autonomic neuropathy (CAN). Additionally, all data related to the patients' average hemoglobin (HbA1c) levels over the last year and the past 5 years and the monitoring and insulin delivery technology used were collected.
View Article and Find Full Text PDFComparative miRNAome combined with transcriptome and degradome analysis reveals a novel miRNA-mRNA regulatory network associated with starch metabolism affecting pre-harvest sprouting resistance in wheat.
BMC Plant Biol
January 2025
Hongshan Laboratory, College of Plant Science & Technology, Huazhong Agricultural University, Wuhan, Hubei, China.
Background: Pre-harvest sprouting (PHS) is one of the most important problems associated with the severe decrease of yield and quality under disaster weather of continuous rain in wheat harvesting stage. At present, the functions and mechanisms related to the involvement of post-transcriptional regulation has not been studied very clearly in PHS resistance.
Results: This study compared the differences of germinated seeds in miRNAome between the PHS-tolerant and PHS-susceptible white wheat varieties.
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